COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations

Coronavirus-19 disease (COVID-19) affects more people than previous coronavirus infections and has a higher mortality. Higher incidence and mortality can probably be explained by COVID-19 causative agent’s greater affinity (about 10–20 times) for angiotensin-converting enzyme 2 (ACE2) receptor compa...

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Autores principales: Canale, Maria Paola, Menghini, Rossella, Martelli, Eugenio, Federici, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556628/
https://www.ncbi.nlm.nih.gov/pubmed/35221082
http://dx.doi.org/10.1016/j.ccep.2021.10.003
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author Canale, Maria Paola
Menghini, Rossella
Martelli, Eugenio
Federici, Massimo
author_facet Canale, Maria Paola
Menghini, Rossella
Martelli, Eugenio
Federici, Massimo
author_sort Canale, Maria Paola
collection PubMed
description Coronavirus-19 disease (COVID-19) affects more people than previous coronavirus infections and has a higher mortality. Higher incidence and mortality can probably be explained by COVID-19 causative agent’s greater affinity (about 10–20 times) for angiotensin-converting enzyme 2 (ACE2) receptor compared with other coronaviruses. Here, the authors first summarize clinical manifestations, then present symptoms of COVID-19 and the pathophysiological mechanisms underlying specific organ/system disease. The worse clinical outcome observed in COVID-19 patients with diabetes may be in part related to the increased ADAM17 activity and its unbalanced interplay with ACE2. Therefore, strategies aimed to inhibit ADAM17 activity may be explored to develop new effective therapeutic approaches.
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spelling pubmed-85566282021-11-01 COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations Canale, Maria Paola Menghini, Rossella Martelli, Eugenio Federici, Massimo Card Electrophysiol Clin Article Coronavirus-19 disease (COVID-19) affects more people than previous coronavirus infections and has a higher mortality. Higher incidence and mortality can probably be explained by COVID-19 causative agent’s greater affinity (about 10–20 times) for angiotensin-converting enzyme 2 (ACE2) receptor compared with other coronaviruses. Here, the authors first summarize clinical manifestations, then present symptoms of COVID-19 and the pathophysiological mechanisms underlying specific organ/system disease. The worse clinical outcome observed in COVID-19 patients with diabetes may be in part related to the increased ADAM17 activity and its unbalanced interplay with ACE2. Therefore, strategies aimed to inhibit ADAM17 activity may be explored to develop new effective therapeutic approaches. Elsevier Inc. 2022-03 2021-10-30 /pmc/articles/PMC8556628/ /pubmed/35221082 http://dx.doi.org/10.1016/j.ccep.2021.10.003 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Canale, Maria Paola
Menghini, Rossella
Martelli, Eugenio
Federici, Massimo
COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title_full COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title_fullStr COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title_full_unstemmed COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title_short COVID-19–Associated Endothelial Dysfunction and Microvascular Injury: From Pathophysiology to Clinical Manifestations
title_sort covid-19–associated endothelial dysfunction and microvascular injury: from pathophysiology to clinical manifestations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556628/
https://www.ncbi.nlm.nih.gov/pubmed/35221082
http://dx.doi.org/10.1016/j.ccep.2021.10.003
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AT martellieugenio covid19associatedendothelialdysfunctionandmicrovascularinjuryfrompathophysiologytoclinicalmanifestations
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