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Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report

Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmeno...

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Autores principales: Dinis de Sousa, Magno, Barata, Margarida, Miranda, Ana Raquel, Sequeira, Pedro, Oliveira, Ana, Xavier, Luísa, Mansinho, Hélder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556653/
https://www.ncbi.nlm.nih.gov/pubmed/34754749
http://dx.doi.org/10.1016/j.rmcr.2021.101528
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author Dinis de Sousa, Magno
Barata, Margarida
Miranda, Ana Raquel
Sequeira, Pedro
Oliveira, Ana
Xavier, Luísa
Mansinho, Hélder
author_facet Dinis de Sousa, Magno
Barata, Margarida
Miranda, Ana Raquel
Sequeira, Pedro
Oliveira, Ana
Xavier, Luísa
Mansinho, Hélder
author_sort Dinis de Sousa, Magno
collection PubMed
description Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmenopausal female, smoker, who presented a 5-month history of progressive dyspnea, dry paroxysmal cough, and significant weight loss. She was referred by a local hospital with the preliminary diagnosis of gestational trophoblastic neoplasia due to a rapidly growing thoracic tumor with persistently elevated serum β-HCG. Computed tomography of the chest showed a lung mass in the right upper lobe associated with homolateral pleural effusion. Positron emission tomography showed pathological 2-[(18)F]FDG uptake at the mass lesion. Biopsies were performed. Histological examination described pleomorphic carcinoma with positive immunostaining for β-HCG. The serum levels of β-HCG were also elevated indicating ectopic secretion. The patient had rapid clinical deterioration and deceased before chemotherapy initiation. Only a few cases of paraneoplastic β-HCG secretion have been reported in the literature. Previous studies suggested that the ability to secrete β-hCG in tumors may correlate to some extent to chemoresistance; thus, it might be useful as a prognosis marker.
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spelling pubmed-85566532021-11-08 Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report Dinis de Sousa, Magno Barata, Margarida Miranda, Ana Raquel Sequeira, Pedro Oliveira, Ana Xavier, Luísa Mansinho, Hélder Respir Med Case Rep Case Report Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmenopausal female, smoker, who presented a 5-month history of progressive dyspnea, dry paroxysmal cough, and significant weight loss. She was referred by a local hospital with the preliminary diagnosis of gestational trophoblastic neoplasia due to a rapidly growing thoracic tumor with persistently elevated serum β-HCG. Computed tomography of the chest showed a lung mass in the right upper lobe associated with homolateral pleural effusion. Positron emission tomography showed pathological 2-[(18)F]FDG uptake at the mass lesion. Biopsies were performed. Histological examination described pleomorphic carcinoma with positive immunostaining for β-HCG. The serum levels of β-HCG were also elevated indicating ectopic secretion. The patient had rapid clinical deterioration and deceased before chemotherapy initiation. Only a few cases of paraneoplastic β-HCG secretion have been reported in the literature. Previous studies suggested that the ability to secrete β-hCG in tumors may correlate to some extent to chemoresistance; thus, it might be useful as a prognosis marker. Elsevier 2021-10-21 /pmc/articles/PMC8556653/ /pubmed/34754749 http://dx.doi.org/10.1016/j.rmcr.2021.101528 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Dinis de Sousa, Magno
Barata, Margarida
Miranda, Ana Raquel
Sequeira, Pedro
Oliveira, Ana
Xavier, Luísa
Mansinho, Hélder
Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title_full Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title_fullStr Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title_full_unstemmed Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title_short Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
title_sort beta-hcg secretion by a pulmonary pleomorphic carcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556653/
https://www.ncbi.nlm.nih.gov/pubmed/34754749
http://dx.doi.org/10.1016/j.rmcr.2021.101528
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