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Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report
Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmeno...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556653/ https://www.ncbi.nlm.nih.gov/pubmed/34754749 http://dx.doi.org/10.1016/j.rmcr.2021.101528 |
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author | Dinis de Sousa, Magno Barata, Margarida Miranda, Ana Raquel Sequeira, Pedro Oliveira, Ana Xavier, Luísa Mansinho, Hélder |
author_facet | Dinis de Sousa, Magno Barata, Margarida Miranda, Ana Raquel Sequeira, Pedro Oliveira, Ana Xavier, Luísa Mansinho, Hélder |
author_sort | Dinis de Sousa, Magno |
collection | PubMed |
description | Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmenopausal female, smoker, who presented a 5-month history of progressive dyspnea, dry paroxysmal cough, and significant weight loss. She was referred by a local hospital with the preliminary diagnosis of gestational trophoblastic neoplasia due to a rapidly growing thoracic tumor with persistently elevated serum β-HCG. Computed tomography of the chest showed a lung mass in the right upper lobe associated with homolateral pleural effusion. Positron emission tomography showed pathological 2-[(18)F]FDG uptake at the mass lesion. Biopsies were performed. Histological examination described pleomorphic carcinoma with positive immunostaining for β-HCG. The serum levels of β-HCG were also elevated indicating ectopic secretion. The patient had rapid clinical deterioration and deceased before chemotherapy initiation. Only a few cases of paraneoplastic β-HCG secretion have been reported in the literature. Previous studies suggested that the ability to secrete β-hCG in tumors may correlate to some extent to chemoresistance; thus, it might be useful as a prognosis marker. |
format | Online Article Text |
id | pubmed-8556653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-85566532021-11-08 Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report Dinis de Sousa, Magno Barata, Margarida Miranda, Ana Raquel Sequeira, Pedro Oliveira, Ana Xavier, Luísa Mansinho, Hélder Respir Med Case Rep Case Report Ectopic secretion of beta-subunit of human chorionic gonadotropin (β-HCG) in pulmonary pleomorphic carcinoma is remarkably rare. Such unusual ectopic hormone production by lung cancer may be initially misinterpreted as extragonadal choriocarcinoma or germ cell tumor. We report a 56-year-old postmenopausal female, smoker, who presented a 5-month history of progressive dyspnea, dry paroxysmal cough, and significant weight loss. She was referred by a local hospital with the preliminary diagnosis of gestational trophoblastic neoplasia due to a rapidly growing thoracic tumor with persistently elevated serum β-HCG. Computed tomography of the chest showed a lung mass in the right upper lobe associated with homolateral pleural effusion. Positron emission tomography showed pathological 2-[(18)F]FDG uptake at the mass lesion. Biopsies were performed. Histological examination described pleomorphic carcinoma with positive immunostaining for β-HCG. The serum levels of β-HCG were also elevated indicating ectopic secretion. The patient had rapid clinical deterioration and deceased before chemotherapy initiation. Only a few cases of paraneoplastic β-HCG secretion have been reported in the literature. Previous studies suggested that the ability to secrete β-hCG in tumors may correlate to some extent to chemoresistance; thus, it might be useful as a prognosis marker. Elsevier 2021-10-21 /pmc/articles/PMC8556653/ /pubmed/34754749 http://dx.doi.org/10.1016/j.rmcr.2021.101528 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Dinis de Sousa, Magno Barata, Margarida Miranda, Ana Raquel Sequeira, Pedro Oliveira, Ana Xavier, Luísa Mansinho, Hélder Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title | Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title_full | Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title_fullStr | Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title_full_unstemmed | Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title_short | Beta-HCG secretion by a pulmonary pleomorphic carcinoma: A case report |
title_sort | beta-hcg secretion by a pulmonary pleomorphic carcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556653/ https://www.ncbi.nlm.nih.gov/pubmed/34754749 http://dx.doi.org/10.1016/j.rmcr.2021.101528 |
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