Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies

The clinicopathological heterogeneity in Lewy-body diseases (LBD) highlights the need for pathology-driven biomarkers in-vivo. Misfolded alpha-synuclein (α-Syn) is a lead candidate based on its crucial role in disease pathophysiology. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF ha...

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Detalles Bibliográficos
Autores principales: Brockmann, Kathrin, Quadalti, Corinne, Lerche, Stefanie, Rossi, Marcello, Wurster, Isabel, Baiardi, Simone, Roeben, Benjamin, Mammana, Angela, Zimmermann, Milan, Hauser, Ann-Kathrin, Deuschle, Christian, Schulte, Claudia, Waniek, Katharina, Lachmann, Ingolf, Sjödin, Simon, Brinkmalm, Ann, Blennow, Kaj, Zetterberg, Henrik, Gasser, Thomas, Parchi, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556894/
https://www.ncbi.nlm.nih.gov/pubmed/34717775
http://dx.doi.org/10.1186/s40478-021-01276-6

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