Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment

Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can prom...

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Autores principales: Wen, Caining, Xu, Limei, Xu, Xiao, Wang, Daping, Liang, Yujie, Duan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556920/
https://www.ncbi.nlm.nih.gov/pubmed/34717735
http://dx.doi.org/10.1186/s13075-021-02662-0
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author Wen, Caining
Xu, Limei
Xu, Xiao
Wang, Daping
Liang, Yujie
Duan, Li
author_facet Wen, Caining
Xu, Limei
Xu, Xiao
Wang, Daping
Liang, Yujie
Duan, Li
author_sort Wen, Caining
collection PubMed
description Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy.
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spelling pubmed-85569202021-11-01 Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment Wen, Caining Xu, Limei Xu, Xiao Wang, Daping Liang, Yujie Duan, Li Arthritis Res Ther Review Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a family of growth factors that are structurally closely related to pro-insulin and can promote chondrocyte proliferation, enhance matrix production, and inhibit chondrocyte apoptosis. Here, we reviewed the role of IGF-1 in cartilage anabolism and catabolism. Moreover, we discussed the potential role of IGF-1 in OA treatment. Of note, we summarized the recent progress on IGF delivery systems. Optimization of IGF delivery systems will facilitate treatment application in cartilage repair and improve OA treatment efficacy. BioMed Central 2021-10-30 2021 /pmc/articles/PMC8556920/ /pubmed/34717735 http://dx.doi.org/10.1186/s13075-021-02662-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wen, Caining
Xu, Limei
Xu, Xiao
Wang, Daping
Liang, Yujie
Duan, Li
Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title_full Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title_fullStr Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title_full_unstemmed Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title_short Insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
title_sort insulin-like growth factor-1 in articular cartilage repair for osteoarthritis treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8556920/
https://www.ncbi.nlm.nih.gov/pubmed/34717735
http://dx.doi.org/10.1186/s13075-021-02662-0
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