A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis

We experienced a case of gastric cancer with multiple liver metastases characterized by frequent hypoglycemic attacks. Hypoglycemia was observed on admission. We suspected that the cause of this hypoglycemia was non-islet cell tumor hypoglycemia (NICTH). Staining of the tissue with an insulin-like g...

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Detalles Bibliográficos
Autores principales: Inoue, Naonori, Kawabata, Hideaki, Miyata, Masatoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Gastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557047/
https://www.ncbi.nlm.nih.gov/pubmed/34733600
http://dx.doi.org/10.7759/cureus.18407
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author Inoue, Naonori
Kawabata, Hideaki
Miyata, Masatoshi
author_facet Inoue, Naonori
Kawabata, Hideaki
Miyata, Masatoshi
author_sort Inoue, Naonori
collection PubMed
description We experienced a case of gastric cancer with multiple liver metastases characterized by frequent hypoglycemic attacks. Hypoglycemia was observed on admission. We suspected that the cause of this hypoglycemia was non-islet cell tumor hypoglycemia (NICTH). Staining of the tissue with an insulin-like growth factor (IGF)-II antibody revealed that IGF-II was present in the tumor cells. This finding suggested that the tumor was producing IGF-II, which leads to NICTH. After starting parenteral nutrition, the patient emerged from the hypoglycemic coma. He remained out of the coma until he died of liver failure.
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spelling pubmed-85570472021-11-02 A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis Inoue, Naonori Kawabata, Hideaki Miyata, Masatoshi Cureus Gastroenterology We experienced a case of gastric cancer with multiple liver metastases characterized by frequent hypoglycemic attacks. Hypoglycemia was observed on admission. We suspected that the cause of this hypoglycemia was non-islet cell tumor hypoglycemia (NICTH). Staining of the tissue with an insulin-like growth factor (IGF)-II antibody revealed that IGF-II was present in the tumor cells. This finding suggested that the tumor was producing IGF-II, which leads to NICTH. After starting parenteral nutrition, the patient emerged from the hypoglycemic coma. He remained out of the coma until he died of liver failure. Cureus 2021-09-30 /pmc/articles/PMC8557047/ /pubmed/34733600 http://dx.doi.org/10.7759/cureus.18407 Text en Copyright © 2021, Inoue et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Inoue, Naonori
Kawabata, Hideaki
Miyata, Masatoshi
A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title_full A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title_fullStr A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title_full_unstemmed A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title_short A Case of Advanced Gastric Cancer With Multiple Liver Metastases in Which Hypoglycemic Symptoms Triggered the Diagnosis
title_sort case of advanced gastric cancer with multiple liver metastases in which hypoglycemic symptoms triggered the diagnosis
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557047/
https://www.ncbi.nlm.nih.gov/pubmed/34733600
http://dx.doi.org/10.7759/cureus.18407
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