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ROS as Regulators of Cellular Processes in Melanoma
In this review, we examine the multiple roles of ROS in the pathogenesis of melanoma, focusing on signal transduction and regulation of gene expression. In recent years, different studies have analyzed the dual role of ROS in regulating the redox system, with both negative and positive consequences...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557056/ https://www.ncbi.nlm.nih.gov/pubmed/34725562 http://dx.doi.org/10.1155/2021/1208690 |
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author | Venza, Isabella Venza, Mario Visalli, Maria Lentini, Germana Teti, Diana d'Alcontres, Francesco Stagno |
author_facet | Venza, Isabella Venza, Mario Visalli, Maria Lentini, Germana Teti, Diana d'Alcontres, Francesco Stagno |
author_sort | Venza, Isabella |
collection | PubMed |
description | In this review, we examine the multiple roles of ROS in the pathogenesis of melanoma, focusing on signal transduction and regulation of gene expression. In recent years, different studies have analyzed the dual role of ROS in regulating the redox system, with both negative and positive consequences on human health, depending on cell concentration of these agents. High ROS levels can result from an altered balance between oxidant generation and intracellular antioxidant activity and can produce harmful effects. In contrast, low amounts of ROS are considered beneficial, since they trigger signaling pathways involved in physiological activities and programmed cell death, with protective effects against melanoma. Here, we examine these beneficial roles, which could have interesting implications in melanoma treatment. |
format | Online Article Text |
id | pubmed-8557056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-85570562021-10-31 ROS as Regulators of Cellular Processes in Melanoma Venza, Isabella Venza, Mario Visalli, Maria Lentini, Germana Teti, Diana d'Alcontres, Francesco Stagno Oxid Med Cell Longev Review Article In this review, we examine the multiple roles of ROS in the pathogenesis of melanoma, focusing on signal transduction and regulation of gene expression. In recent years, different studies have analyzed the dual role of ROS in regulating the redox system, with both negative and positive consequences on human health, depending on cell concentration of these agents. High ROS levels can result from an altered balance between oxidant generation and intracellular antioxidant activity and can produce harmful effects. In contrast, low amounts of ROS are considered beneficial, since they trigger signaling pathways involved in physiological activities and programmed cell death, with protective effects against melanoma. Here, we examine these beneficial roles, which could have interesting implications in melanoma treatment. Hindawi 2021-10-23 /pmc/articles/PMC8557056/ /pubmed/34725562 http://dx.doi.org/10.1155/2021/1208690 Text en Copyright © 2021 Isabella Venza et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Venza, Isabella Venza, Mario Visalli, Maria Lentini, Germana Teti, Diana d'Alcontres, Francesco Stagno ROS as Regulators of Cellular Processes in Melanoma |
title | ROS as Regulators of Cellular Processes in Melanoma |
title_full | ROS as Regulators of Cellular Processes in Melanoma |
title_fullStr | ROS as Regulators of Cellular Processes in Melanoma |
title_full_unstemmed | ROS as Regulators of Cellular Processes in Melanoma |
title_short | ROS as Regulators of Cellular Processes in Melanoma |
title_sort | ros as regulators of cellular processes in melanoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557056/ https://www.ncbi.nlm.nih.gov/pubmed/34725562 http://dx.doi.org/10.1155/2021/1208690 |
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