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A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer

BACKGROUND: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are closely interrelated. However, the effect of having a family history of one disease on the risk of another remains undetermined. AIM: The purpose of this meta-analysis was to estimate the prevalence of a family history of C...

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Autores principales: Najafimehr, Hadis, Aghdaei, Hamid Asadzadeh, Pourhoseingholi, Mohamad Amin, Shalmani, Hamid Mohaghegh, Vahedian-Azimi, Amir, Kroh, Matthew, Zali, Mohammad Reza, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557079/
https://www.ncbi.nlm.nih.gov/pubmed/34725546
http://dx.doi.org/10.1155/2021/4874459
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author Najafimehr, Hadis
Aghdaei, Hamid Asadzadeh
Pourhoseingholi, Mohamad Amin
Shalmani, Hamid Mohaghegh
Vahedian-Azimi, Amir
Kroh, Matthew
Zali, Mohammad Reza
Sahebkar, Amirhossein
author_facet Najafimehr, Hadis
Aghdaei, Hamid Asadzadeh
Pourhoseingholi, Mohamad Amin
Shalmani, Hamid Mohaghegh
Vahedian-Azimi, Amir
Kroh, Matthew
Zali, Mohammad Reza
Sahebkar, Amirhossein
author_sort Najafimehr, Hadis
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are closely interrelated. However, the effect of having a family history of one disease on the risk of another remains undetermined. AIM: The purpose of this meta-analysis was to estimate the prevalence of a family history of CRC among patients with IBD, as well as the prevalence of a family history of IBD among patients with CRC. METHODS: PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched to identify studies reporting the prevalence of family history of IBD among patients with CRC, in addition to the prevalence of family history of CRC among IBD patients. Criteria for study inclusion consisted of the following: (1) studies that evaluated either IBD or CRC and dysplasia, (2) included all age groups, and (3) evaluated the family history effects for IBD or CRC. The total number of IBD patients and IBD patients with a family history of CRC and the total number of CRC patients and CRC patients with a family history of IBD were reviewed. The pooled prevalence of diseases was also estimated according to degree of relatives and geographical area. Random-effects models were used for estimating pooled prevalence. RESULTS: A total of 27 studies were included with 26,576 IBD and 9,181 CRC or dysplasia patients. Eligible studies included 13 case-control, 10 cohort, and 4 cross-sectional types. The pooled prevalence of a family history of CRC among patients with IBD was 6% (95% CI: 4-9%). The pooled prevalence for first- and second-degree relatives (11%, 95% CI: 0-37%) was more than that for the other relative subgroups of relatedness degree. The prevalence in the American regions (8% (95% CI: 5-13%)) was higher than that in the others. The pooled prevalence for a family history of IBD among CRC or dysplasia patients was 11% (95% CI: 6-16%). The pooled prevalence for first-degree relatives (13% (95% CI: 3-28%) was higher than that for the other relative subgroups of relatedness degree; it was also greater in American countries (15%, 95% CI: 8-23%). CONCLUSION: This study emphasizes the relationship between a family history of IBD and CRC development. Additionally, there was notable prevalence for a family history of CRC among IBD patients. American countries and first-degree relatives were identified to have a higher prevalence for both disease processes.
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spelling pubmed-85570792021-10-31 A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer Najafimehr, Hadis Aghdaei, Hamid Asadzadeh Pourhoseingholi, Mohamad Amin Shalmani, Hamid Mohaghegh Vahedian-Azimi, Amir Kroh, Matthew Zali, Mohammad Reza Sahebkar, Amirhossein Gastroenterol Res Pract Review Article BACKGROUND: Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are closely interrelated. However, the effect of having a family history of one disease on the risk of another remains undetermined. AIM: The purpose of this meta-analysis was to estimate the prevalence of a family history of CRC among patients with IBD, as well as the prevalence of a family history of IBD among patients with CRC. METHODS: PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched to identify studies reporting the prevalence of family history of IBD among patients with CRC, in addition to the prevalence of family history of CRC among IBD patients. Criteria for study inclusion consisted of the following: (1) studies that evaluated either IBD or CRC and dysplasia, (2) included all age groups, and (3) evaluated the family history effects for IBD or CRC. The total number of IBD patients and IBD patients with a family history of CRC and the total number of CRC patients and CRC patients with a family history of IBD were reviewed. The pooled prevalence of diseases was also estimated according to degree of relatives and geographical area. Random-effects models were used for estimating pooled prevalence. RESULTS: A total of 27 studies were included with 26,576 IBD and 9,181 CRC or dysplasia patients. Eligible studies included 13 case-control, 10 cohort, and 4 cross-sectional types. The pooled prevalence of a family history of CRC among patients with IBD was 6% (95% CI: 4-9%). The pooled prevalence for first- and second-degree relatives (11%, 95% CI: 0-37%) was more than that for the other relative subgroups of relatedness degree. The prevalence in the American regions (8% (95% CI: 5-13%)) was higher than that in the others. The pooled prevalence for a family history of IBD among CRC or dysplasia patients was 11% (95% CI: 6-16%). The pooled prevalence for first-degree relatives (13% (95% CI: 3-28%) was higher than that for the other relative subgroups of relatedness degree; it was also greater in American countries (15%, 95% CI: 8-23%). CONCLUSION: This study emphasizes the relationship between a family history of IBD and CRC development. Additionally, there was notable prevalence for a family history of CRC among IBD patients. American countries and first-degree relatives were identified to have a higher prevalence for both disease processes. Hindawi 2021-10-23 /pmc/articles/PMC8557079/ /pubmed/34725546 http://dx.doi.org/10.1155/2021/4874459 Text en Copyright © 2021 Hadis Najafimehr et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Najafimehr, Hadis
Aghdaei, Hamid Asadzadeh
Pourhoseingholi, Mohamad Amin
Shalmani, Hamid Mohaghegh
Vahedian-Azimi, Amir
Kroh, Matthew
Zali, Mohammad Reza
Sahebkar, Amirhossein
A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title_full A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title_fullStr A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title_full_unstemmed A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title_short A Systematic Review and Meta-Analysis on the Association between Inflammatory Bowel Disease Family History and Colorectal Cancer
title_sort systematic review and meta-analysis on the association between inflammatory bowel disease family history and colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557079/
https://www.ncbi.nlm.nih.gov/pubmed/34725546
http://dx.doi.org/10.1155/2021/4874459
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