Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

Necrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis (Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but how these are interconnected and linked to the release of pro-inflammatory cytokines remains unknown. Exploit...

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Detalles Bibliográficos
Autores principales: Theobald, Sebastian J., Gräb, Jessica, Fritsch, Melanie, Suárez, Isabelle, Eisfeld, Hannah S., Winter, Sandra, Koch, Maximilian, Hölscher, Christoph, Pasparakis, Manolis, Kashkar, Hamid, Rybniker, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557205/
https://www.ncbi.nlm.nih.gov/pubmed/34718331
http://dx.doi.org/10.1038/s41420-021-00716-5

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