Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner

Chemotherapy-induced intestinal mucositis (CIM) is a common adverse reaction to antineoplastic treatment with few appropriate, specific interventions. We aimed to identify the role of the G protein coupled estrogen receptor (GPER) in CIM and its mechanism. Adult male C57BL/6 mice were intraperitonea...

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Detalles Bibliográficos
Autores principales: Chen, Guanyu, Zeng, Honghui, Li, Xinyun, Liu, Jianbo, Li, Zhao, Xu, Runze, Ma, Yuntao, Liu, Chuanyong, Xue, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557214/
https://www.ncbi.nlm.nih.gov/pubmed/34718327
http://dx.doi.org/10.1038/s41419-021-04325-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557214/
https://www.ncbi.nlm.nih.gov/pubmed/34718327
http://dx.doi.org/10.1038/s41419-021-04325-z

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