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Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis
INTRODUCTION: Bioelectrical impedance analysis (BIA) can be used to estimate Fat-Free Mass Index (FFMI). However, the use of directly measured BIA variables, such as phase angle (PhA), has gained attention. The frequency of low FFMI and PhA and its associations with exercise capacity and health-rela...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557280/ https://www.ncbi.nlm.nih.gov/pubmed/34711642 http://dx.doi.org/10.1136/bmjresp-2021-001039 |
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author | Machado, Felipe V C Bloem, Ada E M Schneeberger, Tessa Jarosch, Inga Gloeckl, Rainer Winterkamp, Sandra Franssen, Frits M E Koczulla, Andreas R Pitta, Fabio Spruit, Martijn A Kenn, Klaus |
author_facet | Machado, Felipe V C Bloem, Ada E M Schneeberger, Tessa Jarosch, Inga Gloeckl, Rainer Winterkamp, Sandra Franssen, Frits M E Koczulla, Andreas R Pitta, Fabio Spruit, Martijn A Kenn, Klaus |
author_sort | Machado, Felipe V C |
collection | PubMed |
description | INTRODUCTION: Bioelectrical impedance analysis (BIA) can be used to estimate Fat-Free Mass Index (FFMI). However, the use of directly measured BIA variables, such as phase angle (PhA), has gained attention. The frequency of low FFMI and PhA and its associations with exercise capacity and health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF) have been scarcely studied. OBJECTIVES: To investigate the frequency of low FFMI and PhA and their associations with exercise capacity and HRQL in patients with IPF. METHODS: Patients underwent assessment of lung function, body composition, exercise capacity by the 6 min walk distance (6MWD), and HRQL by the Medical Outcomes Study Short-Form 36-item Questionnaire (SF-36). Patients were classified as presenting normal or low PhA or FFMI, accordingly to the 10th percentiles of age-sex-body mass index (BMI)-specific reference values. RESULTS: 98 patients (84 males, age: 68±8 years, forced vital capacity: 64%±18%predicted) were included. 24 patients presented low PhA. They were characterised by worse lung function, exercise capacity and HRQL compared with patients with normal PhA. 10 patients presented low FFMI, but despite differences in body composition, no differences were found between these patients and patients with normal FFMI. In a single regression analysis, age, lung function and body composition variables (except FFMI) were related to 6MWD and SF-36 Physical Summary Score (R²=0.06–0.36, p<0.05). None of the variables were related to SF-36 Mental Summary Score. CONCLUSION: One-fourth of the patients with IPF with normal to obese BMI present abnormally low PhA. Patients classified as low PhA presented worse lung function, exercise capacity and HRQL. |
format | Online Article Text |
id | pubmed-8557280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-85572802021-11-15 Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis Machado, Felipe V C Bloem, Ada E M Schneeberger, Tessa Jarosch, Inga Gloeckl, Rainer Winterkamp, Sandra Franssen, Frits M E Koczulla, Andreas R Pitta, Fabio Spruit, Martijn A Kenn, Klaus BMJ Open Respir Res Interstitial Lung Disease INTRODUCTION: Bioelectrical impedance analysis (BIA) can be used to estimate Fat-Free Mass Index (FFMI). However, the use of directly measured BIA variables, such as phase angle (PhA), has gained attention. The frequency of low FFMI and PhA and its associations with exercise capacity and health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF) have been scarcely studied. OBJECTIVES: To investigate the frequency of low FFMI and PhA and their associations with exercise capacity and HRQL in patients with IPF. METHODS: Patients underwent assessment of lung function, body composition, exercise capacity by the 6 min walk distance (6MWD), and HRQL by the Medical Outcomes Study Short-Form 36-item Questionnaire (SF-36). Patients were classified as presenting normal or low PhA or FFMI, accordingly to the 10th percentiles of age-sex-body mass index (BMI)-specific reference values. RESULTS: 98 patients (84 males, age: 68±8 years, forced vital capacity: 64%±18%predicted) were included. 24 patients presented low PhA. They were characterised by worse lung function, exercise capacity and HRQL compared with patients with normal PhA. 10 patients presented low FFMI, but despite differences in body composition, no differences were found between these patients and patients with normal FFMI. In a single regression analysis, age, lung function and body composition variables (except FFMI) were related to 6MWD and SF-36 Physical Summary Score (R²=0.06–0.36, p<0.05). None of the variables were related to SF-36 Mental Summary Score. CONCLUSION: One-fourth of the patients with IPF with normal to obese BMI present abnormally low PhA. Patients classified as low PhA presented worse lung function, exercise capacity and HRQL. BMJ Publishing Group 2021-10-28 /pmc/articles/PMC8557280/ /pubmed/34711642 http://dx.doi.org/10.1136/bmjresp-2021-001039 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Interstitial Lung Disease Machado, Felipe V C Bloem, Ada E M Schneeberger, Tessa Jarosch, Inga Gloeckl, Rainer Winterkamp, Sandra Franssen, Frits M E Koczulla, Andreas R Pitta, Fabio Spruit, Martijn A Kenn, Klaus Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title | Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title_full | Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title_fullStr | Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title_full_unstemmed | Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title_short | Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
title_sort | relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis |
topic | Interstitial Lung Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557280/ https://www.ncbi.nlm.nih.gov/pubmed/34711642 http://dx.doi.org/10.1136/bmjresp-2021-001039 |
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