Cargando…

Reliability of the AR-CALUX(®)In Vitro Method Used to Detect Chemicals with (Anti)Androgen Activity: Results of an International Ring Trial

The AR-CALUX(®) in vitro method is a reporter gene-based transactivation method where endocrine active chemicals with androgenic or anti-androgenic potential can be detected. Its primary purpose is for screening chemicals for further prioritization and providing mechanistic (endocrine mode of action...

Descripción completa

Detalles Bibliográficos
Autores principales:	Milcamps, Anne, Liska, Roman, Langezaal, Ingrid, Casey, Warren, Dent, Matthew, Odum, Jenny
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Regulatory Science, Risk Assessment, and Decision Making
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557474/ https://www.ncbi.nlm.nih.gov/pubmed/34165557 http://dx.doi.org/10.1093/toxsci/kfab078

Ejemplares similares

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow
por: Middleton, Alistair M, et al.
Publicado: (2022)

A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products
por: Baltazar, Maria T, et al.
Publicado: (2020)

Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury
por: Monroe, James J, et al.
Publicado: (2020)

Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
por: Mallick, Pankajini, et al.
Publicado: (2020)

Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident
por: Matar, Hazem, et al.
Publicado: (2019)

Bioelution, Bioavailability, and Toxicity of Cobalt Compounds Correlate
por: Danzeisen, Ruth, et al.
Publicado: (2020)

Potential of ToxCast Data in the Safety Assessment of Food Chemicals
por: Punt, Ans, et al.
Publicado: (2020)

A Survey of Systematic Evidence Mapping Practice and the Case for Knowledge Graphs in Environmental Health and Toxicology
por: Wolffe, Taylor A M, et al.
Publicado: (2020)

Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt
por: Lenz, Barbara, et al.
Publicado: (2021)

Application of a Framework for Grouping and Mixtures Toxicity Assessment of PFAS: A Closer Examination of Dose-Additivity Approaches
por: Goodrum, Philip E, et al.
Publicado: (2020)

Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species
por: Hardwick, Rhiannon N, et al.
Publicado: (2022)

Manganese relative oral bioavailability in electric arc furnace steel slag is influenced by high iron content and low bioaccessibility
por: Proctor, Deborah M, et al.
Publicado: (2023)

A mode of action-based probabilistic framework of dose-response assessment for nonmutagenic liver carcinogens: a case study of PCB-126
por: Zhou, Yun, et al.
Publicado: (2023)

Managing wildlife populations with uncertainty: cormorants Phalacrocorax carbo
por: Smith, G C, et al.
Publicado: (2008)

Family History Is a Predictor for Appendicitis in Adults in the Emergency Department
por: Drescher, Michael J., et al.
Publicado: (2012)

Carprofen and local anaesthesia in calves undergoing disbudding
por: Wareham, Kathryn, et al.
Publicado: (2015)

Renal diets in cats with chronic kidney disease
por: Dean, Rachel, et al.
Publicado: (2015)

REVIEW: Towards a risk register for natural capital
por: Mace, Georgina M., et al.
Publicado: (2015)

Approach to the Diagnosis and Management of Subarachnoid Hemorrhage
por: Marcolini, Evie, et al.
Publicado: (2019)

Review of the Basics of Cognitive Error in Emergency Medicine: Still No Easy Answers
por: Hartigan, Sarah, et al.
Publicado: (2020)

Estimating the effects of Cry1F Bt‐maize pollen on non‐target Lepidoptera using a mathematical model of exposure
por: Perry, Joe N., et al.
Publicado: (2012)

Construction of a risk assessment model of cardiovascular disease in a rural Chinese hypertensive population based on lasso‐Cox analysis
por: Ouyang, Nanxiang, et al.
Publicado: (2021)

Results of Ring‐Testing of a Semifield Study Design to Investigate Potential Impacts of Crop Protection Products on Bumblebees (Hymenoptera, Apidae) and a Proposal of a Potential Test Design
por: Klein, Olaf, et al.
Publicado: (2022)

Results of 2‐Year Ring Testing of a Semifield Study Design to Investigate Potential Impacts of Plant Protection Products on the Solitary Bees Osmia Bicornis and Osmia Cornuta and a Proposal for a Suitable Test Design
por: Franke, Lea, et al.
Publicado: (2020)

Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data
por: Dent, Matthew P, et al.
Publicado: (2019)

A METHOD TO PREDICT AND UNDERSTAND FISH SURVIVAL UNDER DYNAMIC CHEMICAL STRESS USING STANDARD ECOTOXICITY DATA
por: Ashauer, Roman, et al.
Publicado: (2013)

Crítica de la decisión
por: Sfez, Lucien
Publicado: (1984)

Coupling the H295R with ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities
por: Nikopaschou, Martha S, et al.
Publicado: (2023)

Drug Lag and Key Regulatory Barriers in the Emerging Markets
por: Wileman, Harriet, et al.
Publicado: (2010)

Regulations and guidelines governing stem cell based products: Clinical considerations
por: George, Bobby
Publicado: (2011)

Regulatory Considerations for Biosimilars
por: Nellore, Ranjani
Publicado: (2010)

Registration of Medical Devices
por: George, Bobby
Publicado: (2010)

Implications of ICH-E5: Assessment of drug's sensitivity to ethnic factors and necessity of a bridging study for global drug development
por: Gupta, Sandeep Kumar
Publicado: (2011)

Regulatory requirements for marketing fixed dose combinations
por: Jayasheel, B. G.
Publicado: (2010)

Injury and death in clinical trials and compensation: Rule 122 DAB
por: Ghooi, Ravindra. B.
Publicado: (2013)

Key points of technical review for the registration of SARS-CoV-2 antigen/antibody tests
por: Li, Hongran, et al.
Publicado: (2021)

China NMPA perspective on clinical evaluation of SARS-CoV-2 antibody test reagents in the process of emergency approval
por: Lv, Yunfeng, et al.
Publicado: (2020)

Key points of technical review for the registration of SARS-CoV-2 nucleic acid tests in China
por: Li, Hongran, et al.
Publicado: (2021)

China's NMPA perspective on the clinical performance of SARS-CoV-2 antigen test reagents
por: Lv, Yunfeng, et al.
Publicado: (2022)

Does GLP enhance the quality of toxicological evidence for regulatory decisions?
por: Borgert, Christopher J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_oj6n6ih7aftjpohpq75cjbom8t