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Long noncoding RNA SNHG4: a novel target in human diseases

Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small...

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Autores principales: Chu, Qingfei, Gu, Xinyu, Zheng, Qiuxian, Guo, Zixuan, Shan, Dandan, Wang, Jing, Zhu, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557547/
https://www.ncbi.nlm.nih.gov/pubmed/34717631
http://dx.doi.org/10.1186/s12935-021-02292-1
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author Chu, Qingfei
Gu, Xinyu
Zheng, Qiuxian
Guo, Zixuan
Shan, Dandan
Wang, Jing
Zhu, Haihong
author_facet Chu, Qingfei
Gu, Xinyu
Zheng, Qiuxian
Guo, Zixuan
Shan, Dandan
Wang, Jing
Zhu, Haihong
author_sort Chu, Qingfei
collection PubMed
description Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member of the lncRNA SNHG family, is abnormally expressed in a variety of human diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate cancer, colorectal cancer, osteosarcoma, cervical cancer, liver cancer, lung cancer, non-small-cell lung cancer, neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, acute myeloid leukaemia, and endometriosis. In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SNHG4 in the above diseases. In addition, the specific mechanism of SNHG4 as a competing endogenous RNA (ceRNA) is discussed. The findings indicate that SNHG4 can be used as a biomarker for disease prognosis evaluation and as a potential target for disease diagnosis and treatment.
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spelling pubmed-85575472021-11-01 Long noncoding RNA SNHG4: a novel target in human diseases Chu, Qingfei Gu, Xinyu Zheng, Qiuxian Guo, Zixuan Shan, Dandan Wang, Jing Zhu, Haihong Cancer Cell Int Review Recently, long noncoding RNAs (lncRNAs) have attracted great attention from researchers. LncRNAs are non-protein-coding RNAs of more than 200 nucleotides in length. Multiple studies have been published on the relationship between lncRNA expression and the progression of human diseases. LncRNA small nucleolar RNA host gene 4 (SNHG4), a member of the lncRNA SNHG family, is abnormally expressed in a variety of human diseases, including gastric cancer, renal cell carcinoma, glioblastoma, neuroblastoma, prostate cancer, colorectal cancer, osteosarcoma, cervical cancer, liver cancer, lung cancer, non-small-cell lung cancer, neonatal pneumonia, diabetic retinopathy, neuropathic pain, acute cerebral infarction, acute myeloid leukaemia, and endometriosis. In this paper, the structure of SNHG4 is first introduced, and then studies in humans, animal models and cells are summarized to highlight the expression and function of SNHG4 in the above diseases. In addition, the specific mechanism of SNHG4 as a competing endogenous RNA (ceRNA) is discussed. The findings indicate that SNHG4 can be used as a biomarker for disease prognosis evaluation and as a potential target for disease diagnosis and treatment. BioMed Central 2021-10-30 /pmc/articles/PMC8557547/ /pubmed/34717631 http://dx.doi.org/10.1186/s12935-021-02292-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chu, Qingfei
Gu, Xinyu
Zheng, Qiuxian
Guo, Zixuan
Shan, Dandan
Wang, Jing
Zhu, Haihong
Long noncoding RNA SNHG4: a novel target in human diseases
title Long noncoding RNA SNHG4: a novel target in human diseases
title_full Long noncoding RNA SNHG4: a novel target in human diseases
title_fullStr Long noncoding RNA SNHG4: a novel target in human diseases
title_full_unstemmed Long noncoding RNA SNHG4: a novel target in human diseases
title_short Long noncoding RNA SNHG4: a novel target in human diseases
title_sort long noncoding rna snhg4: a novel target in human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557547/
https://www.ncbi.nlm.nih.gov/pubmed/34717631
http://dx.doi.org/10.1186/s12935-021-02292-1
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