Synergistic stimulation of osteoblast differentiation of rat mesenchymal stem cells by leptin and 25(OH)D(3) is mediated by inhibition of chaperone-mediated autophagy

BACKGROUND: Vitamin D is important for the mineralization of bones by stimulating osteoblast differentiation of bone marrow mesenchymal stem cells (BMMSCs). BMMSCs are a target of vitamin D action, and the metabolism of 25(OH)D(3) to biologically active 1α,25(OH)(2)D(3) in BMMSCs promotes osteoblast...

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Detalles Bibliográficos
Autores principales: He, Qiting, Qin, Ruixi, Glowacki, Julie, Zhou, Shuanhu, Shi, Jie, Wang, Shaoyi, Gao, Yuan, Cheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557551/
https://www.ncbi.nlm.nih.gov/pubmed/34717752
http://dx.doi.org/10.1186/s13287-021-02623-z

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