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Nanomedicine for increasing the oral bioavailability of cancer treatments

ABSTRACT: Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent dec...

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Detalles Bibliográficos
Autores principales: Parodi, Alessandro, Buzaeva, Polina, Nigovora, Daria, Baldin, Alexey, Kostyushev, Dmitry, Chulanov, Vladimir, Savvateeva, Lyudmila V., Zamyatnin, Andrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557561/
https://www.ncbi.nlm.nih.gov/pubmed/34717658
http://dx.doi.org/10.1186/s12951-021-01100-2
Descripción
Sumario:ABSTRACT: Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines. GRAPHICAL ABSTRACT: [Image: see text]