Nanomedicine for increasing the oral bioavailability of cancer treatments

ABSTRACT: Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent dec...

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Autores principales: Parodi, Alessandro, Buzaeva, Polina, Nigovora, Daria, Baldin, Alexey, Kostyushev, Dmitry, Chulanov, Vladimir, Savvateeva, Lyudmila V., Zamyatnin, Andrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557561/
https://www.ncbi.nlm.nih.gov/pubmed/34717658
http://dx.doi.org/10.1186/s12951-021-01100-2
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author Parodi, Alessandro
Buzaeva, Polina
Nigovora, Daria
Baldin, Alexey
Kostyushev, Dmitry
Chulanov, Vladimir
Savvateeva, Lyudmila V.
Zamyatnin, Andrey A.
author_facet Parodi, Alessandro
Buzaeva, Polina
Nigovora, Daria
Baldin, Alexey
Kostyushev, Dmitry
Chulanov, Vladimir
Savvateeva, Lyudmila V.
Zamyatnin, Andrey A.
author_sort Parodi, Alessandro
collection PubMed
description ABSTRACT: Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-85575612021-11-01 Nanomedicine for increasing the oral bioavailability of cancer treatments Parodi, Alessandro Buzaeva, Polina Nigovora, Daria Baldin, Alexey Kostyushev, Dmitry Chulanov, Vladimir Savvateeva, Lyudmila V. Zamyatnin, Andrey A. J Nanobiotechnology Review ABSTRACT: Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrease the bioavailability of medications, including chemotherapeutics. In recent decades, the fields of material science and nanomedicine have generated several delivery platforms with high potential for overcoming multiple barriers associated to oral administration. This review describes the properties of several nanodelivery systems that improve the bioavailability of orally administered therapeutics, highlighting their advantages and disadvantages in generating successful anticancer oral nanomedicines. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2021-10-30 /pmc/articles/PMC8557561/ /pubmed/34717658 http://dx.doi.org/10.1186/s12951-021-01100-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Parodi, Alessandro
Buzaeva, Polina
Nigovora, Daria
Baldin, Alexey
Kostyushev, Dmitry
Chulanov, Vladimir
Savvateeva, Lyudmila V.
Zamyatnin, Andrey A.
Nanomedicine for increasing the oral bioavailability of cancer treatments
title Nanomedicine for increasing the oral bioavailability of cancer treatments
title_full Nanomedicine for increasing the oral bioavailability of cancer treatments
title_fullStr Nanomedicine for increasing the oral bioavailability of cancer treatments
title_full_unstemmed Nanomedicine for increasing the oral bioavailability of cancer treatments
title_short Nanomedicine for increasing the oral bioavailability of cancer treatments
title_sort nanomedicine for increasing the oral bioavailability of cancer treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557561/
https://www.ncbi.nlm.nih.gov/pubmed/34717658
http://dx.doi.org/10.1186/s12951-021-01100-2
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