Mesenchymal stem cells-derived exosomes for drug delivery

Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many...

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Detalles Bibliográficos
Autores principales: Sun, Yao, Liu, Guoliang, Zhang, Kai, Cao, Qian, Liu, Tongjun, Li, Jiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557580/
https://www.ncbi.nlm.nih.gov/pubmed/34717769
http://dx.doi.org/10.1186/s13287-021-02629-7
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author Sun, Yao
Liu, Guoliang
Zhang, Kai
Cao, Qian
Liu, Tongjun
Li, Jiannan
author_facet Sun, Yao
Liu, Guoliang
Zhang, Kai
Cao, Qian
Liu, Tongjun
Li, Jiannan
author_sort Sun, Yao
collection PubMed
description Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies.
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spelling pubmed-85575802021-11-03 Mesenchymal stem cells-derived exosomes for drug delivery Sun, Yao Liu, Guoliang Zhang, Kai Cao, Qian Liu, Tongjun Li, Jiannan Stem Cell Res Ther Review Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for drug delivery. Targeted drug delivery in the body is a promising method for treating many refractory diseases such as tumors and Alzheimer's disease (AD). Finding a suitable drug delivery carrier in the body has become a popular research today. In various drug delivery studies, the exosomes secreted by mesenchymal stem cells (MSC-EXOs) have been broadly researched due to their immune properties, tumor-homing properties, and elastic properties. While MSC-EXOs have apparent advantages, some unresolved problems also exist. This article reviews the studies on MSC-EXOs for drug delivery, summarizes the characteristics of MSC-EXOs, and introduces the primary production and purification methods and drug loading methods to provide solutions for existing problems and suggestions for future studies. BioMed Central 2021-10-30 /pmc/articles/PMC8557580/ /pubmed/34717769 http://dx.doi.org/10.1186/s13287-021-02629-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Yao
Liu, Guoliang
Zhang, Kai
Cao, Qian
Liu, Tongjun
Li, Jiannan
Mesenchymal stem cells-derived exosomes for drug delivery
title Mesenchymal stem cells-derived exosomes for drug delivery
title_full Mesenchymal stem cells-derived exosomes for drug delivery
title_fullStr Mesenchymal stem cells-derived exosomes for drug delivery
title_full_unstemmed Mesenchymal stem cells-derived exosomes for drug delivery
title_short Mesenchymal stem cells-derived exosomes for drug delivery
title_sort mesenchymal stem cells-derived exosomes for drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557580/
https://www.ncbi.nlm.nih.gov/pubmed/34717769
http://dx.doi.org/10.1186/s13287-021-02629-7
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AT liutongjun mesenchymalstemcellsderivedexosomesfordrugdelivery
AT lijiannan mesenchymalstemcellsderivedexosomesfordrugdelivery

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