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A dashboard for exploring clinical trials sponsorship and potential virtual monopolies

OBJECTIVE: To create a data visualization dashboard to advance research related to clinical trials sponsorship and monopolistic practices in the pharmaceuticals industry. MATERIALS AND METHODS: This R Shiny application aggregates data from ClinicialTrials.gov resulting from user’s queries by terms....

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Detalles Bibliográficos
Autores principales: Graham, S Scott, Majdik, Zoltan P, Barbour, Joshua B, Rousseau, Justin F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557741/
https://www.ncbi.nlm.nih.gov/pubmed/34729462
http://dx.doi.org/10.1093/jamiaopen/ooab089
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author Graham, S Scott
Majdik, Zoltan P
Barbour, Joshua B
Rousseau, Justin F
author_facet Graham, S Scott
Majdik, Zoltan P
Barbour, Joshua B
Rousseau, Justin F
author_sort Graham, S Scott
collection PubMed
description OBJECTIVE: To create a data visualization dashboard to advance research related to clinical trials sponsorship and monopolistic practices in the pharmaceuticals industry. MATERIALS AND METHODS: This R Shiny application aggregates data from ClinicialTrials.gov resulting from user’s queries by terms. Returned data are visualized through an interactive dashboard. RESULTS: The Clinical Trials Sponsorship Network Dashboard (CTSND) uses force-directed network mapping algorithms to visualize clinical trials sponsorship data. Interpretation of network visualization is further supported with data on sponsor classes, sponsorship timelines, evaluated products, and target conditions. The source code for the CTSND is available at https://github.com/sscottgraham/ConflictMetrics. DISCUSSION: Monopolistic practices have been identified as a likely contributor to high drug prices in the United States. CTSND data and visualizations support the analysis of clinical trials sponsorship networks and may aid in identifying current and emerging monopolistic practices. CONCLUSIONS: CTSND data can support more robust deliberation about an understudied area of drug pricing.
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spelling pubmed-85577412021-11-01 A dashboard for exploring clinical trials sponsorship and potential virtual monopolies Graham, S Scott Majdik, Zoltan P Barbour, Joshua B Rousseau, Justin F JAMIA Open Application Notes OBJECTIVE: To create a data visualization dashboard to advance research related to clinical trials sponsorship and monopolistic practices in the pharmaceuticals industry. MATERIALS AND METHODS: This R Shiny application aggregates data from ClinicialTrials.gov resulting from user’s queries by terms. Returned data are visualized through an interactive dashboard. RESULTS: The Clinical Trials Sponsorship Network Dashboard (CTSND) uses force-directed network mapping algorithms to visualize clinical trials sponsorship data. Interpretation of network visualization is further supported with data on sponsor classes, sponsorship timelines, evaluated products, and target conditions. The source code for the CTSND is available at https://github.com/sscottgraham/ConflictMetrics. DISCUSSION: Monopolistic practices have been identified as a likely contributor to high drug prices in the United States. CTSND data and visualizations support the analysis of clinical trials sponsorship networks and may aid in identifying current and emerging monopolistic practices. CONCLUSIONS: CTSND data can support more robust deliberation about an understudied area of drug pricing. Oxford University Press 2021-10-29 /pmc/articles/PMC8557741/ /pubmed/34729462 http://dx.doi.org/10.1093/jamiaopen/ooab089 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Medical Informatics Association. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Application Notes
Graham, S Scott
Majdik, Zoltan P
Barbour, Joshua B
Rousseau, Justin F
A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title_full A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title_fullStr A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title_full_unstemmed A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title_short A dashboard for exploring clinical trials sponsorship and potential virtual monopolies
title_sort dashboard for exploring clinical trials sponsorship and potential virtual monopolies
topic Application Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557741/
https://www.ncbi.nlm.nih.gov/pubmed/34729462
http://dx.doi.org/10.1093/jamiaopen/ooab089
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