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High-Order Epistasis and Functional Coupling of Infection Steps Drive Virus Evolution toward Independence from a Host Pathway
The phosphatidylinositol-4 kinase IIIβ (PI4KB)/oxysterol-binding protein (OSBP) family I pathway serves as an essential host pathway for the formation of viral replication complex for viral plus-strand RNA synthesis; however, poliovirus (PV) could evolve toward substantial independence from this hos...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Microbiology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8557862/ https://www.ncbi.nlm.nih.gov/pubmed/34468191 http://dx.doi.org/10.1128/Spectrum.00800-21 |