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Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China

BACKGROUND: Founder events have been observed among numerous plants and animal species living on oceanic islands due to the geographic separation of these islands and the small amount of original life they harbor. However, there has been little research on the ecological characteristics of pathogeni...

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Autores principales: Geng, Yuanyuan, Wu, Weiwei, Li, Rouyu, Xu, Juan, Gu, Ruixue, Lu, Jiejie, Zheng, Wenai, Zhao, Fei, Zhang, Jianzhong, Gong, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558103/
https://www.ncbi.nlm.nih.gov/pubmed/34737596
http://dx.doi.org/10.2147/CCID.S329569
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author Geng, Yuanyuan
Wu, Weiwei
Li, Rouyu
Xu, Juan
Gu, Ruixue
Lu, Jiejie
Zheng, Wenai
Zhao, Fei
Zhang, Jianzhong
Gong, Jie
author_facet Geng, Yuanyuan
Wu, Weiwei
Li, Rouyu
Xu, Juan
Gu, Ruixue
Lu, Jiejie
Zheng, Wenai
Zhao, Fei
Zhang, Jianzhong
Gong, Jie
author_sort Geng, Yuanyuan
collection PubMed
description BACKGROUND: Founder events have been observed among numerous plants and animal species living on oceanic islands due to the geographic separation of these islands and the small amount of original life they harbor. However, there has been little research on the ecological characteristics of pathogenic microorganisms on islands. Trichophyton rubrum ranks the most common isolated dermatophyte causing dermatophytosis in clinic and has become an epidemic strain worldwide in recent decades. OBJECTIVE: To study the phylogenetic characteristics and the distribution pattern of genetic polymorphism of T. rubrum in China, which further provide theoretical basis for the prevention and control of T. rubrum. METHODS: In the present study, we sequenced and analyzed the genetic characteristics of 204 T. rubrum isolates from Hainan Island and other sites in China. Phylogenetic analysis and genetic polymorphisms were studied based on a total of 41,409 high-quality whole-genome SNPs. RESULTS: The majority of the isolates from Hainan Island clustered together. Mixed T. rubrum population differentiation was observed among the strains of different geographical origins. In addition, the genetic diversity (π) of the Hainan isolates was low and showed no significant difference from that of isolates from other sites. CONCLUSION: This study is the first to discuss general ecological and evolutionary principles related to pathogenic fungi. Our findings reveal a founder effect during the origination of T. rubrum on Hainan Island and provide guidance regarding prevention and treatment strategies.
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spelling pubmed-85581032021-11-03 Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China Geng, Yuanyuan Wu, Weiwei Li, Rouyu Xu, Juan Gu, Ruixue Lu, Jiejie Zheng, Wenai Zhao, Fei Zhang, Jianzhong Gong, Jie Clin Cosmet Investig Dermatol Original Research BACKGROUND: Founder events have been observed among numerous plants and animal species living on oceanic islands due to the geographic separation of these islands and the small amount of original life they harbor. However, there has been little research on the ecological characteristics of pathogenic microorganisms on islands. Trichophyton rubrum ranks the most common isolated dermatophyte causing dermatophytosis in clinic and has become an epidemic strain worldwide in recent decades. OBJECTIVE: To study the phylogenetic characteristics and the distribution pattern of genetic polymorphism of T. rubrum in China, which further provide theoretical basis for the prevention and control of T. rubrum. METHODS: In the present study, we sequenced and analyzed the genetic characteristics of 204 T. rubrum isolates from Hainan Island and other sites in China. Phylogenetic analysis and genetic polymorphisms were studied based on a total of 41,409 high-quality whole-genome SNPs. RESULTS: The majority of the isolates from Hainan Island clustered together. Mixed T. rubrum population differentiation was observed among the strains of different geographical origins. In addition, the genetic diversity (π) of the Hainan isolates was low and showed no significant difference from that of isolates from other sites. CONCLUSION: This study is the first to discuss general ecological and evolutionary principles related to pathogenic fungi. Our findings reveal a founder effect during the origination of T. rubrum on Hainan Island and provide guidance regarding prevention and treatment strategies. Dove 2021-10-27 /pmc/articles/PMC8558103/ /pubmed/34737596 http://dx.doi.org/10.2147/CCID.S329569 Text en © 2021 Geng et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Geng, Yuanyuan
Wu, Weiwei
Li, Rouyu
Xu, Juan
Gu, Ruixue
Lu, Jiejie
Zheng, Wenai
Zhao, Fei
Zhang, Jianzhong
Gong, Jie
Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title_full Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title_fullStr Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title_full_unstemmed Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title_short Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis Pathogen Trichophyton rubrum on Hainan Island, China
title_sort founder effects contribute to the population genetic structure of the major dermatophytosis pathogen trichophyton rubrum on hainan island, china
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558103/
https://www.ncbi.nlm.nih.gov/pubmed/34737596
http://dx.doi.org/10.2147/CCID.S329569
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