The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells

BACKGROUND: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. METHOD: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4...

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Autores principales: Lee, In-Song, Chang, Jun-Ho, Kim, Dae-Won, Kim, Seong-Gon, Kim, Tae-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558123/
https://www.ncbi.nlm.nih.gov/pubmed/34719767
http://dx.doi.org/10.1186/s40902-021-00326-2
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author Lee, In-Song
Chang, Jun-Ho
Kim, Dae-Won
Kim, Seong-Gon
Kim, Tae-Woo
author_facet Lee, In-Song
Chang, Jun-Ho
Kim, Dae-Won
Kim, Seong-Gon
Kim, Tae-Woo
author_sort Lee, In-Song
collection PubMed
description BACKGROUND: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. METHOD: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. RESULTS: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). CONCLUSION: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells.
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spelling pubmed-85581232021-11-15 The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells Lee, In-Song Chang, Jun-Ho Kim, Dae-Won Kim, Seong-Gon Kim, Tae-Woo Maxillofac Plast Reconstr Surg Research BACKGROUND: 4-hexylresorcinol (4HR) has been shown to have anti-oxidant activity similar to that of resveratrol. As resveratrol increases sirtuin (SIRT) activity, 4HR might behave similarly to resveratrol. METHOD: In this study, the expression levels of SIRT1, SIRT3, and SIRT6 were evaluated after 4HR administration (1–100 μM). As NAD+ is a substrate for SIRTs, its levels with SIRT activity were also studied. RESULTS: In the results, SIRT3 (100 μM at 24 h) and SIRT6 (1–100 μM at 24 h and 10 μM at 8 h) were shown to have significantly higher expression levels compared to untreated control (p < 0.05). Pan-SIRT activity and the NAD+ level was significantly increased compared to that of the untreated control (p < 0.05; 10 and 100 μM at 24 h). CONCLUSION: 4HR administration increased SIRT activity and the NAD+ level in Saos-2 cells. Springer Singapore 2021-11-01 /pmc/articles/PMC8558123/ /pubmed/34719767 http://dx.doi.org/10.1186/s40902-021-00326-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Lee, In-Song
Chang, Jun-Ho
Kim, Dae-Won
Kim, Seong-Gon
Kim, Tae-Woo
The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_full The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_fullStr The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_full_unstemmed The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_short The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells
title_sort effect of 4-hexylresorinol administration on nad+ level and sirt activity in saos-2 cells
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558123/
https://www.ncbi.nlm.nih.gov/pubmed/34719767
http://dx.doi.org/10.1186/s40902-021-00326-2
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