The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released through C-terminal cleavage of CCL21, C21TP, boosts...

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Detalles Bibliográficos
Autores principales: Jørgensen, Astrid Sissel, Brandum, Emma Probst, Mikkelsen, Jeppe Malthe, Orfin, Klaudia A., Boilesen, Ditte Rahbæk, Egerod, Kristoffer Lihme, Moussouras, Natasha A., Vilhardt, Frederik, Kalinski, Pawel, Basse, Per, Chen, Yen-Hsi, Yang, Zhang, Dwinell, Michael B., Volkman, Brian F., Veldkamp, Christopher T., Holst, Peter Johannes, Lahl, Katharina, Goth, Christoffer Knak, Rosenkilde, Mette Marie, Hjortø, Gertrud Malene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558179/
https://www.ncbi.nlm.nih.gov/pubmed/34586443
http://dx.doi.org/10.1007/s00018-021-03930-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558179/
https://www.ncbi.nlm.nih.gov/pubmed/34586443
http://dx.doi.org/10.1007/s00018-021-03930-7

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