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Primary metabolic processes as drivers of leaf ageing

Ageing in plants is a highly coordinated and complex process that starts with the birth of the plant or plant organ and ends with its death. A vivid manifestation of the final stage of leaf ageing is exemplified by the autumn colours of deciduous trees. Over the past decades, technological advances...

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Autores principales: Kanojia, Aakansha, Shrestha, Deny K., Dijkwel, Paul P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558203/
https://www.ncbi.nlm.nih.gov/pubmed/34279698
http://dx.doi.org/10.1007/s00018-021-03896-6
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author Kanojia, Aakansha
Shrestha, Deny K.
Dijkwel, Paul P.
author_facet Kanojia, Aakansha
Shrestha, Deny K.
Dijkwel, Paul P.
author_sort Kanojia, Aakansha
collection PubMed
description Ageing in plants is a highly coordinated and complex process that starts with the birth of the plant or plant organ and ends with its death. A vivid manifestation of the final stage of leaf ageing is exemplified by the autumn colours of deciduous trees. Over the past decades, technological advances have allowed plant ageing to be studied on a systems biology level, by means of multi-omics approaches. Here, we review some of these studies and argue that these provide strong support for basic metabolic processes as drivers for ageing. In particular, core cellular processes that control the metabolism of chlorophyll, amino acids, sugars, DNA and reactive oxygen species correlate with leaf ageing. However, while multi-omics studies excel at identifying correlative processes and pathways, molecular genetic approaches can provide proof that such processes and pathways control ageing, by means of knock-out and ectopic expression of predicted regulatory genes. Therefore, we also review historic and current molecular evidence to directly test the hypotheses unveiled by the systems biology approaches. We found that the molecular genetic approaches, by and large, confirm the multi-omics-derived hypotheses with notable exceptions, where there is scant evidence that chlorophyll and DNA metabolism are important drivers of leaf ageing. We present a model that summarises the core cellular processes that drive leaf ageing and propose that developmental processes are tightly linked to primary metabolism to inevitably lead to ageing and death.
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spelling pubmed-85582032021-11-15 Primary metabolic processes as drivers of leaf ageing Kanojia, Aakansha Shrestha, Deny K. Dijkwel, Paul P. Cell Mol Life Sci Review Ageing in plants is a highly coordinated and complex process that starts with the birth of the plant or plant organ and ends with its death. A vivid manifestation of the final stage of leaf ageing is exemplified by the autumn colours of deciduous trees. Over the past decades, technological advances have allowed plant ageing to be studied on a systems biology level, by means of multi-omics approaches. Here, we review some of these studies and argue that these provide strong support for basic metabolic processes as drivers for ageing. In particular, core cellular processes that control the metabolism of chlorophyll, amino acids, sugars, DNA and reactive oxygen species correlate with leaf ageing. However, while multi-omics studies excel at identifying correlative processes and pathways, molecular genetic approaches can provide proof that such processes and pathways control ageing, by means of knock-out and ectopic expression of predicted regulatory genes. Therefore, we also review historic and current molecular evidence to directly test the hypotheses unveiled by the systems biology approaches. We found that the molecular genetic approaches, by and large, confirm the multi-omics-derived hypotheses with notable exceptions, where there is scant evidence that chlorophyll and DNA metabolism are important drivers of leaf ageing. We present a model that summarises the core cellular processes that drive leaf ageing and propose that developmental processes are tightly linked to primary metabolism to inevitably lead to ageing and death. Springer International Publishing 2021-07-19 2021 /pmc/articles/PMC8558203/ /pubmed/34279698 http://dx.doi.org/10.1007/s00018-021-03896-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kanojia, Aakansha
Shrestha, Deny K.
Dijkwel, Paul P.
Primary metabolic processes as drivers of leaf ageing
title Primary metabolic processes as drivers of leaf ageing
title_full Primary metabolic processes as drivers of leaf ageing
title_fullStr Primary metabolic processes as drivers of leaf ageing
title_full_unstemmed Primary metabolic processes as drivers of leaf ageing
title_short Primary metabolic processes as drivers of leaf ageing
title_sort primary metabolic processes as drivers of leaf ageing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558203/
https://www.ncbi.nlm.nih.gov/pubmed/34279698
http://dx.doi.org/10.1007/s00018-021-03896-6
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