Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade

The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca(2+) sensor in the endoplasmic reticulum (ER), and Orai1, the Ca(2+) ion channel in the plasma membrane. Ca(2+) store depletion triggers conformational changes and oligomerization of STIM1 proteins and their direct interacti...

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Detalles Bibliográficos
Autores principales: Höglinger, Carmen, Grabmayr, Herwig, Maltan, Lena, Horvath, Ferdinand, Krobath, Heinrich, Muik, Martin, Tiffner, Adela, Renger, Thomas, Romanin, Christoph, Fahrner, Marc, Derler, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558294/
https://www.ncbi.nlm.nih.gov/pubmed/34498097
http://dx.doi.org/10.1007/s00018-021-03933-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558294/
https://www.ncbi.nlm.nih.gov/pubmed/34498097
http://dx.doi.org/10.1007/s00018-021-03933-4

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