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Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy

Purpose: To evaluate the long-term retinal microvascular, neural, and choroidal changes in the patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP). Methods: Forty-five eyes of 28 patients with trea...

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Autores principales: Huang, Tian, Li, Xiaoli, Xie, Jie, Zhang, Liang, Zhang, Guanrong, Zhang, Aiping, Chen, Xiangting, Cui, Ying, Meng, Qianli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558304/
https://www.ncbi.nlm.nih.gov/pubmed/34733867
http://dx.doi.org/10.3389/fmed.2021.752538
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author Huang, Tian
Li, Xiaoli
Xie, Jie
Zhang, Liang
Zhang, Guanrong
Zhang, Aiping
Chen, Xiangting
Cui, Ying
Meng, Qianli
author_facet Huang, Tian
Li, Xiaoli
Xie, Jie
Zhang, Liang
Zhang, Guanrong
Zhang, Aiping
Chen, Xiangting
Cui, Ying
Meng, Qianli
author_sort Huang, Tian
collection PubMed
description Purpose: To evaluate the long-term retinal microvascular, neural, and choroidal changes in the patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP). Methods: Forty-five eyes of 28 patients with treatment-naive severe NPDR and PDR were included and followed for 12 months after PRP. Microvascular and neural changes in the macular and peripapillary areas were assessed by using optical coherence tomography angiography. Subfoveal choroidal thickness (SFCT) was measured by using optical coherence tomography. A Linear mixed-effects model was used to highlight the differences for the variables after adjusting for sex, age, and axial length. Results: Compared to baseline, there were no statistical differences in the best corrected visual acuity (BCVA), macular and peripapillary vessel density (VD), and SFCT following PRP. Macular thickness significantly increased at 1 and 3–6 months after PRP (p < 0.05), while the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness significantly increased at 1 month postoperatively (p < 0.01). Global loss volume and focal loss volume significantly decreased at the same time point (p < 0.05). Conclusion: The unchanged BCVA, VD, the thickness of RNFL and GCC, and SFCT during the 12-month follow-up period suggest that PRP may prevent the retinal neurovascular and choroidal damage.
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spelling pubmed-85583042021-11-02 Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy Huang, Tian Li, Xiaoli Xie, Jie Zhang, Liang Zhang, Guanrong Zhang, Aiping Chen, Xiangting Cui, Ying Meng, Qianli Front Med (Lausanne) Medicine Purpose: To evaluate the long-term retinal microvascular, neural, and choroidal changes in the patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP). Methods: Forty-five eyes of 28 patients with treatment-naive severe NPDR and PDR were included and followed for 12 months after PRP. Microvascular and neural changes in the macular and peripapillary areas were assessed by using optical coherence tomography angiography. Subfoveal choroidal thickness (SFCT) was measured by using optical coherence tomography. A Linear mixed-effects model was used to highlight the differences for the variables after adjusting for sex, age, and axial length. Results: Compared to baseline, there were no statistical differences in the best corrected visual acuity (BCVA), macular and peripapillary vessel density (VD), and SFCT following PRP. Macular thickness significantly increased at 1 and 3–6 months after PRP (p < 0.05), while the peripapillary retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness significantly increased at 1 month postoperatively (p < 0.01). Global loss volume and focal loss volume significantly decreased at the same time point (p < 0.05). Conclusion: The unchanged BCVA, VD, the thickness of RNFL and GCC, and SFCT during the 12-month follow-up period suggest that PRP may prevent the retinal neurovascular and choroidal damage. Frontiers Media S.A. 2021-10-18 /pmc/articles/PMC8558304/ /pubmed/34733867 http://dx.doi.org/10.3389/fmed.2021.752538 Text en Copyright © 2021 Huang, Li, Xie, Zhang, Zhang, Zhang, Chen, Cui and Meng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Huang, Tian
Li, Xiaoli
Xie, Jie
Zhang, Liang
Zhang, Guanrong
Zhang, Aiping
Chen, Xiangting
Cui, Ying
Meng, Qianli
Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title_full Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title_fullStr Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title_full_unstemmed Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title_short Long-Term Retinal Neurovascular and Choroidal Changes After Panretinal Photocoagulation in Diabetic Retinopathy
title_sort long-term retinal neurovascular and choroidal changes after panretinal photocoagulation in diabetic retinopathy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558304/
https://www.ncbi.nlm.nih.gov/pubmed/34733867
http://dx.doi.org/10.3389/fmed.2021.752538
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