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Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India

Objectives: The growing prevalence of dementia, especially in low- and middle-income countries (LMICs), has raised the need for a unified cognitive screening tool that can aid its early detection. The linguistically and educationally diverse population in India contributes to challenges in diagnosis...

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Autores principales: Verma, Mansi, Tripathi, Manjari, Nehra, Ashima, Paplikar, Avanthi, Varghese, Feba, Alladi, Suvarna, Narayanan, Jwala, Dhaliwal, R. S., Sharma, Meenakshi, Saroja, Aralikatte Onkarappa, Arshad, Faheem, Divyaraj, Gollahalli, Ghosh, Amitabha, Manae, Tejaswini S., Mekala, Shailaja, Menon, Ramshekhar N., Hooda, Roopa, Iyer, Gowri K., Sunitha, J., Kandukuri, Rajmohan, Kaul, Subhash, Khan, Arfa Banu, Mathew, Robert, Nandi, Ranita, Padma, M. V., Pauranik, Apoorva, Ramakrishnan, Subasree, Sarath, Lekha, Shah, Urvashi, Sylaja, P. N., Varma, Ravi Prasad, Vishwanath, Yeshaswini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558406/
https://www.ncbi.nlm.nih.gov/pubmed/34733226
http://dx.doi.org/10.3389/fneur.2021.661269
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author Verma, Mansi
Tripathi, Manjari
Nehra, Ashima
Paplikar, Avanthi
Varghese, Feba
Alladi, Suvarna
Narayanan, Jwala
Dhaliwal, R. S.
Sharma, Meenakshi
Saroja, Aralikatte Onkarappa
Arshad, Faheem
Divyaraj, Gollahalli
Ghosh, Amitabha
Manae, Tejaswini S.
Mekala, Shailaja
Menon, Ramshekhar N.
Hooda, Roopa
Iyer, Gowri K.
Sunitha, J.
Kandukuri, Rajmohan
Kaul, Subhash
Khan, Arfa Banu
Mathew, Robert
Nandi, Ranita
Padma, M. V.
Pauranik, Apoorva
Ramakrishnan, Subasree
Sarath, Lekha
Shah, Urvashi
Sylaja, P. N.
Varma, Ravi Prasad
Vishwanath, Yeshaswini
author_facet Verma, Mansi
Tripathi, Manjari
Nehra, Ashima
Paplikar, Avanthi
Varghese, Feba
Alladi, Suvarna
Narayanan, Jwala
Dhaliwal, R. S.
Sharma, Meenakshi
Saroja, Aralikatte Onkarappa
Arshad, Faheem
Divyaraj, Gollahalli
Ghosh, Amitabha
Manae, Tejaswini S.
Mekala, Shailaja
Menon, Ramshekhar N.
Hooda, Roopa
Iyer, Gowri K.
Sunitha, J.
Kandukuri, Rajmohan
Kaul, Subhash
Khan, Arfa Banu
Mathew, Robert
Nandi, Ranita
Padma, M. V.
Pauranik, Apoorva
Ramakrishnan, Subasree
Sarath, Lekha
Shah, Urvashi
Sylaja, P. N.
Varma, Ravi Prasad
Vishwanath, Yeshaswini
author_sort Verma, Mansi
collection PubMed
description Objectives: The growing prevalence of dementia, especially in low- and middle-income countries (LMICs), has raised the need for a unified cognitive screening tool that can aid its early detection. The linguistically and educationally diverse population in India contributes to challenges in diagnosis. The present study aimed to assess the validity and diagnostic accuracy of the Indian Council of Medical Research-Neurocognitive Toolbox (ICMR-NCTB), a comprehensive neuropsychological test battery adapted in five languages, for the diagnosis of dementia. Methods: A multidisciplinary group of experts developed the ICMR-NCTB based on reviewing the existing tools and incorporation of culturally appropriate modifications. The finalized tests of the major cognitive domains of attention, executive functions, memory, language, and visuospatial skills were then adapted and translated into five Indian languages: Hindi, Bengali, Telugu, Kannada, and Malayalam. Three hundred fifty-four participants were recruited, including 222 controls and 132 dementia patients. The sensitivity and specificity of the adapted tests were established for the diagnosis of dementia. Results: A significant difference in the mean (median) performance scores between healthy controls and patients with dementia was observed on all tests of ICMR-NCTB. The area under the curve for majority of the tests included in the ICMR-NCTB ranged from 0.73 to 1.00, and the sensitivity and specificity of the ICMR-NCTB tests ranged from 70 to 100% and 70.7 to 100%, respectively, to identify dementia across all five languages. Conclusions: The ICMR-NCTB is a valid instrument to diagnose dementia across five Indian languages, with good diagnostic accuracy. The toolbox was effective in overcoming the challenge of linguistic diversity. The study has wide implications to address the problem of a high disease burden and low diagnostic rate of dementia in LMICs like India.
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spelling pubmed-85584062021-11-02 Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India Verma, Mansi Tripathi, Manjari Nehra, Ashima Paplikar, Avanthi Varghese, Feba Alladi, Suvarna Narayanan, Jwala Dhaliwal, R. S. Sharma, Meenakshi Saroja, Aralikatte Onkarappa Arshad, Faheem Divyaraj, Gollahalli Ghosh, Amitabha Manae, Tejaswini S. Mekala, Shailaja Menon, Ramshekhar N. Hooda, Roopa Iyer, Gowri K. Sunitha, J. Kandukuri, Rajmohan Kaul, Subhash Khan, Arfa Banu Mathew, Robert Nandi, Ranita Padma, M. V. Pauranik, Apoorva Ramakrishnan, Subasree Sarath, Lekha Shah, Urvashi Sylaja, P. N. Varma, Ravi Prasad Vishwanath, Yeshaswini Front Neurol Neurology Objectives: The growing prevalence of dementia, especially in low- and middle-income countries (LMICs), has raised the need for a unified cognitive screening tool that can aid its early detection. The linguistically and educationally diverse population in India contributes to challenges in diagnosis. The present study aimed to assess the validity and diagnostic accuracy of the Indian Council of Medical Research-Neurocognitive Toolbox (ICMR-NCTB), a comprehensive neuropsychological test battery adapted in five languages, for the diagnosis of dementia. Methods: A multidisciplinary group of experts developed the ICMR-NCTB based on reviewing the existing tools and incorporation of culturally appropriate modifications. The finalized tests of the major cognitive domains of attention, executive functions, memory, language, and visuospatial skills were then adapted and translated into five Indian languages: Hindi, Bengali, Telugu, Kannada, and Malayalam. Three hundred fifty-four participants were recruited, including 222 controls and 132 dementia patients. The sensitivity and specificity of the adapted tests were established for the diagnosis of dementia. Results: A significant difference in the mean (median) performance scores between healthy controls and patients with dementia was observed on all tests of ICMR-NCTB. The area under the curve for majority of the tests included in the ICMR-NCTB ranged from 0.73 to 1.00, and the sensitivity and specificity of the ICMR-NCTB tests ranged from 70 to 100% and 70.7 to 100%, respectively, to identify dementia across all five languages. Conclusions: The ICMR-NCTB is a valid instrument to diagnose dementia across five Indian languages, with good diagnostic accuracy. The toolbox was effective in overcoming the challenge of linguistic diversity. The study has wide implications to address the problem of a high disease burden and low diagnostic rate of dementia in LMICs like India. Frontiers Media S.A. 2021-10-18 /pmc/articles/PMC8558406/ /pubmed/34733226 http://dx.doi.org/10.3389/fneur.2021.661269 Text en Copyright © 2021 Verma, Tripathi, Nehra, Paplikar, Varghese, Alladi, Narayanan, Dhaliwal, Sharma, Saroja, Arshad, Divyaraj, Ghosh, Manae, Mekala, Menon, Hooda, Iyer, Sunitha, Kandukuri, Kaul, Khan, Mathew, Nandi, Padma, Pauranik, Ramakrishnan, Sarath, Shah, Sylaja, Varma and Vishwanath. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Verma, Mansi
Tripathi, Manjari
Nehra, Ashima
Paplikar, Avanthi
Varghese, Feba
Alladi, Suvarna
Narayanan, Jwala
Dhaliwal, R. S.
Sharma, Meenakshi
Saroja, Aralikatte Onkarappa
Arshad, Faheem
Divyaraj, Gollahalli
Ghosh, Amitabha
Manae, Tejaswini S.
Mekala, Shailaja
Menon, Ramshekhar N.
Hooda, Roopa
Iyer, Gowri K.
Sunitha, J.
Kandukuri, Rajmohan
Kaul, Subhash
Khan, Arfa Banu
Mathew, Robert
Nandi, Ranita
Padma, M. V.
Pauranik, Apoorva
Ramakrishnan, Subasree
Sarath, Lekha
Shah, Urvashi
Sylaja, P. N.
Varma, Ravi Prasad
Vishwanath, Yeshaswini
Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title_full Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title_fullStr Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title_full_unstemmed Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title_short Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India
title_sort validation of icmr neurocognitive toolbox for dementia in the linguistically diverse context of india
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558406/
https://www.ncbi.nlm.nih.gov/pubmed/34733226
http://dx.doi.org/10.3389/fneur.2021.661269
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