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A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development
As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558413/ https://www.ncbi.nlm.nih.gov/pubmed/34733856 http://dx.doi.org/10.3389/fcell.2021.762651 |
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author | Shi, Di Jiang, Peng |
author_facet | Shi, Di Jiang, Peng |
author_sort | Shi, Di |
collection | PubMed |
description | As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well-known roles of p53, accumulating evidence show that p53 also regulates innate immune and adaptive immune responses. p53 influences the innate immune system by secreted factors that modulate macrophage function to suppress tumourigenesis. Dysfunction of p53 in cancer affects the activity and recruitment of T and myeloid cells, resulting in immune evasion. p53 can also activate key regulators in immune signaling pathways which support or impede tumor development. Hence, it seems that the tumor suppressor p53 exerts its tumor suppressive effect to a considerable extent by modulating the immune response. In this review, we concisely discuss the emerging connections between p53 and immune responses, and their impact on tumor progression. Understanding the role of p53 in regulation of immunity will help to developing more effective anti-tumor immunotherapies for patients with TP53 mutation or depletion. |
format | Online Article Text |
id | pubmed-8558413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85584132021-11-02 A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development Shi, Di Jiang, Peng Front Cell Dev Biol Cell and Developmental Biology As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well-known roles of p53, accumulating evidence show that p53 also regulates innate immune and adaptive immune responses. p53 influences the innate immune system by secreted factors that modulate macrophage function to suppress tumourigenesis. Dysfunction of p53 in cancer affects the activity and recruitment of T and myeloid cells, resulting in immune evasion. p53 can also activate key regulators in immune signaling pathways which support or impede tumor development. Hence, it seems that the tumor suppressor p53 exerts its tumor suppressive effect to a considerable extent by modulating the immune response. In this review, we concisely discuss the emerging connections between p53 and immune responses, and their impact on tumor progression. Understanding the role of p53 in regulation of immunity will help to developing more effective anti-tumor immunotherapies for patients with TP53 mutation or depletion. Frontiers Media S.A. 2021-10-18 /pmc/articles/PMC8558413/ /pubmed/34733856 http://dx.doi.org/10.3389/fcell.2021.762651 Text en Copyright © 2021 Shi and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Shi, Di Jiang, Peng A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title | A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title_full | A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title_fullStr | A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title_full_unstemmed | A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title_short | A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development |
title_sort | different facet of p53 function: regulation of immunity and inflammation during tumor development |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558413/ https://www.ncbi.nlm.nih.gov/pubmed/34733856 http://dx.doi.org/10.3389/fcell.2021.762651 |
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