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Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella

OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In total, 36 patients undergoing EESBS for les...

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Autores principales: Raikundalia, Milap D., Huang, Ryan J., Chan, Lyndon, Truong, Tracy, Kuchibhatla, Maragatha, Merchant, James, Hachem, Ralph Abi, Codd, Patrick J., Zomorodi, Ali R., Teitelbaum, Jordan I., Goldstein, Bradley J., Jang, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558591/
https://www.ncbi.nlm.nih.gov/pubmed/34733580
http://dx.doi.org/10.1177/21526567211045041
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author Raikundalia, Milap D.
Huang, Ryan J.
Chan, Lyndon
Truong, Tracy
Kuchibhatla, Maragatha
Merchant, James
Hachem, Ralph Abi
Codd, Patrick J.
Zomorodi, Ali R.
Teitelbaum, Jordan I.
Goldstein, Bradley J.
Jang, David W.
author_facet Raikundalia, Milap D.
Huang, Ryan J.
Chan, Lyndon
Truong, Tracy
Kuchibhatla, Maragatha
Merchant, James
Hachem, Ralph Abi
Codd, Patrick J.
Zomorodi, Ali R.
Teitelbaum, Jordan I.
Goldstein, Bradley J.
Jang, David W.
author_sort Raikundalia, Milap D.
collection PubMed
description OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In total, 36 patients undergoing EESBS for lesions limited to the sella were evaluated. MAIN OUTCOME MEASURES: The following were performed before and three months after surgery: 22-Item Sinonasal Outcomes Test (SNOT-22), University of Pennsylvania Smell Identification Test (UPSIT), and the Assessment of Self-reported Olfactory Functioning (ASOF), which has three domains: subjective olfactory capability scale (SOC), smell-related problems (SRP), and olfactory-related quality of life (ORQ). RESULTS: Median age at surgery was 52.5 years, with a median tumor size of 1.8 cm (range: 0.2 to 3.9 cm). Pre- and postoperative median scores were 35 [34, 36.2] and 34.5 [32, 36] for UPSIT, 21 [7.5, 33.5] and 21.5 [6.8, 35.7] for SNOT-22, 10 [9, 10] and 9 [8, 10] for ASOF-SOC, 5 [4.8, 5] and 4.5 [4, 5] for ASOF-SRP, and 5 [5, 5] and 5 [4.5, 5] for ASOF-ORQ. There was no significant change in the two of the three domains of the ASOF. Correlation between ASOF and UPSIT scores were weak. Older age and larger tumor size were associated with worsened olfaction after surgery. CONCLUSIONS: Patients did not experience significant changes in olfactory-specific QOL three months after EESBS, as measured by two domains of the ASOF. The ASOF may serve as a useful adjunctive tool for assessing olfaction after surgery. The lack of correlation between UPSIT and ASOF suggests the need for more research in subjective olfactory-related quality of life after surgery.
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spelling pubmed-85585912021-11-02 Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella Raikundalia, Milap D. Huang, Ryan J. Chan, Lyndon Truong, Tracy Kuchibhatla, Maragatha Merchant, James Hachem, Ralph Abi Codd, Patrick J. Zomorodi, Ali R. Teitelbaum, Jordan I. Goldstein, Bradley J. Jang, David W. Allergy Rhinol (Providence) Original Research Article OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In total, 36 patients undergoing EESBS for lesions limited to the sella were evaluated. MAIN OUTCOME MEASURES: The following were performed before and three months after surgery: 22-Item Sinonasal Outcomes Test (SNOT-22), University of Pennsylvania Smell Identification Test (UPSIT), and the Assessment of Self-reported Olfactory Functioning (ASOF), which has three domains: subjective olfactory capability scale (SOC), smell-related problems (SRP), and olfactory-related quality of life (ORQ). RESULTS: Median age at surgery was 52.5 years, with a median tumor size of 1.8 cm (range: 0.2 to 3.9 cm). Pre- and postoperative median scores were 35 [34, 36.2] and 34.5 [32, 36] for UPSIT, 21 [7.5, 33.5] and 21.5 [6.8, 35.7] for SNOT-22, 10 [9, 10] and 9 [8, 10] for ASOF-SOC, 5 [4.8, 5] and 4.5 [4, 5] for ASOF-SRP, and 5 [5, 5] and 5 [4.5, 5] for ASOF-ORQ. There was no significant change in the two of the three domains of the ASOF. Correlation between ASOF and UPSIT scores were weak. Older age and larger tumor size were associated with worsened olfaction after surgery. CONCLUSIONS: Patients did not experience significant changes in olfactory-specific QOL three months after EESBS, as measured by two domains of the ASOF. The ASOF may serve as a useful adjunctive tool for assessing olfaction after surgery. The lack of correlation between UPSIT and ASOF suggests the need for more research in subjective olfactory-related quality of life after surgery. SAGE Publications 2021-10-29 /pmc/articles/PMC8558591/ /pubmed/34733580 http://dx.doi.org/10.1177/21526567211045041 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Raikundalia, Milap D.
Huang, Ryan J.
Chan, Lyndon
Truong, Tracy
Kuchibhatla, Maragatha
Merchant, James
Hachem, Ralph Abi
Codd, Patrick J.
Zomorodi, Ali R.
Teitelbaum, Jordan I.
Goldstein, Bradley J.
Jang, David W.
Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title_full Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title_fullStr Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title_full_unstemmed Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title_short Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella
title_sort olfactory-specific quality of life outcomes after endoscopic endonasal surgery of the sella
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558591/
https://www.ncbi.nlm.nih.gov/pubmed/34733580
http://dx.doi.org/10.1177/21526567211045041
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