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GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells

Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in ca...

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Autores principales: Dang, Yunzhi, Yu, Jiao, Zhao, Shuhong, Jin, Long, Cao, Ximing, Wang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558645/
https://www.ncbi.nlm.nih.gov/pubmed/34729117
http://dx.doi.org/10.7150/jca.61567
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author Dang, Yunzhi
Yu, Jiao
Zhao, Shuhong
Jin, Long
Cao, Ximing
Wang, Qing
author_facet Dang, Yunzhi
Yu, Jiao
Zhao, Shuhong
Jin, Long
Cao, Ximing
Wang, Qing
author_sort Dang, Yunzhi
collection PubMed
description Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in cancer progression. Here, we reported a novel role of GOLM1 in promoting CRC metastasis. In this study, the expression of GOLM1 was detected in human CRC cohort. The function of GOLM1 in CRC metastasis was analyzed by in vivo cecum orthotopic model. We found that the expression of GOLM1 was significantly increased in CRC tissues than adjacent nontumor. Overexpression GOLM1 can promote CRC immune escape and metastasis by recruiting of myeloid-derived suppressor cells (MDSCs) at the same time. PF-04136309, a small molecule and specific inhibitor of CCR2 can largely suppressed GOLM1-mediated CRC metastasis. These results suggest that GOLM1 can promote CRC metastasis and is a prognostic biomarker in human CRC.
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spelling pubmed-85586452021-11-01 GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells Dang, Yunzhi Yu, Jiao Zhao, Shuhong Jin, Long Cao, Ximing Wang, Qing J Cancer Research Paper Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in cancer progression. Here, we reported a novel role of GOLM1 in promoting CRC metastasis. In this study, the expression of GOLM1 was detected in human CRC cohort. The function of GOLM1 in CRC metastasis was analyzed by in vivo cecum orthotopic model. We found that the expression of GOLM1 was significantly increased in CRC tissues than adjacent nontumor. Overexpression GOLM1 can promote CRC immune escape and metastasis by recruiting of myeloid-derived suppressor cells (MDSCs) at the same time. PF-04136309, a small molecule and specific inhibitor of CCR2 can largely suppressed GOLM1-mediated CRC metastasis. These results suggest that GOLM1 can promote CRC metastasis and is a prognostic biomarker in human CRC. Ivyspring International Publisher 2021-10-21 /pmc/articles/PMC8558645/ /pubmed/34729117 http://dx.doi.org/10.7150/jca.61567 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Dang, Yunzhi
Yu, Jiao
Zhao, Shuhong
Jin, Long
Cao, Ximing
Wang, Qing
GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title_full GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title_fullStr GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title_full_unstemmed GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title_short GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
title_sort golm1 drives colorectal cancer metastasis by regulating myeloid-derived suppressor cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558645/
https://www.ncbi.nlm.nih.gov/pubmed/34729117
http://dx.doi.org/10.7150/jca.61567
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