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GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells
Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in ca...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558645/ https://www.ncbi.nlm.nih.gov/pubmed/34729117 http://dx.doi.org/10.7150/jca.61567 |
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author | Dang, Yunzhi Yu, Jiao Zhao, Shuhong Jin, Long Cao, Ximing Wang, Qing |
author_facet | Dang, Yunzhi Yu, Jiao Zhao, Shuhong Jin, Long Cao, Ximing Wang, Qing |
author_sort | Dang, Yunzhi |
collection | PubMed |
description | Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in cancer progression. Here, we reported a novel role of GOLM1 in promoting CRC metastasis. In this study, the expression of GOLM1 was detected in human CRC cohort. The function of GOLM1 in CRC metastasis was analyzed by in vivo cecum orthotopic model. We found that the expression of GOLM1 was significantly increased in CRC tissues than adjacent nontumor. Overexpression GOLM1 can promote CRC immune escape and metastasis by recruiting of myeloid-derived suppressor cells (MDSCs) at the same time. PF-04136309, a small molecule and specific inhibitor of CCR2 can largely suppressed GOLM1-mediated CRC metastasis. These results suggest that GOLM1 can promote CRC metastasis and is a prognostic biomarker in human CRC. |
format | Online Article Text |
id | pubmed-8558645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-85586452021-11-01 GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells Dang, Yunzhi Yu, Jiao Zhao, Shuhong Jin, Long Cao, Ximing Wang, Qing J Cancer Research Paper Colorectal cancer (CRC) is the most common digestive neoplasms worldwide, metastasis and recurrence still account for the leading cause for the high mortality rate, but the exact mechanisms remain unclear. More and more evidence has indicated that the deregulation of GOLM1 plays a crucial role in cancer progression. Here, we reported a novel role of GOLM1 in promoting CRC metastasis. In this study, the expression of GOLM1 was detected in human CRC cohort. The function of GOLM1 in CRC metastasis was analyzed by in vivo cecum orthotopic model. We found that the expression of GOLM1 was significantly increased in CRC tissues than adjacent nontumor. Overexpression GOLM1 can promote CRC immune escape and metastasis by recruiting of myeloid-derived suppressor cells (MDSCs) at the same time. PF-04136309, a small molecule and specific inhibitor of CCR2 can largely suppressed GOLM1-mediated CRC metastasis. These results suggest that GOLM1 can promote CRC metastasis and is a prognostic biomarker in human CRC. Ivyspring International Publisher 2021-10-21 /pmc/articles/PMC8558645/ /pubmed/34729117 http://dx.doi.org/10.7150/jca.61567 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Dang, Yunzhi Yu, Jiao Zhao, Shuhong Jin, Long Cao, Ximing Wang, Qing GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title | GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title_full | GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title_fullStr | GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title_full_unstemmed | GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title_short | GOLM1 Drives Colorectal Cancer Metastasis by Regulating Myeloid-derived Suppressor Cells |
title_sort | golm1 drives colorectal cancer metastasis by regulating myeloid-derived suppressor cells |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558645/ https://www.ncbi.nlm.nih.gov/pubmed/34729117 http://dx.doi.org/10.7150/jca.61567 |
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