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Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review

Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of t...

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Detalles Bibliográficos
Autores principales: Ioffe, Dina, Phull, Pooja, Dotan, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558827/
https://www.ncbi.nlm.nih.gov/pubmed/34737637
http://dx.doi.org/10.2147/CMAR.S276104
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author Ioffe, Dina
Phull, Pooja
Dotan, Efrat
author_facet Ioffe, Dina
Phull, Pooja
Dotan, Efrat
author_sort Ioffe, Dina
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description Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas.
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spelling pubmed-85588272021-11-03 Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review Ioffe, Dina Phull, Pooja Dotan, Efrat Cancer Manag Res Review Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas. Dove 2021-10-27 /pmc/articles/PMC8558827/ /pubmed/34737637 http://dx.doi.org/10.2147/CMAR.S276104 Text en © 2021 Ioffe et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Ioffe, Dina
Phull, Pooja
Dotan, Efrat
Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title_full Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title_fullStr Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title_full_unstemmed Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title_short Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
title_sort optimal management of patients with advanced or metastatic cholangiocarcinoma: an evidence-based review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558827/
https://www.ncbi.nlm.nih.gov/pubmed/34737637
http://dx.doi.org/10.2147/CMAR.S276104
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