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Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review
Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558827/ https://www.ncbi.nlm.nih.gov/pubmed/34737637 http://dx.doi.org/10.2147/CMAR.S276104 |
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author | Ioffe, Dina Phull, Pooja Dotan, Efrat |
author_facet | Ioffe, Dina Phull, Pooja Dotan, Efrat |
author_sort | Ioffe, Dina |
collection | PubMed |
description | Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas. |
format | Online Article Text |
id | pubmed-8558827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-85588272021-11-03 Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review Ioffe, Dina Phull, Pooja Dotan, Efrat Cancer Manag Res Review Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas. Dove 2021-10-27 /pmc/articles/PMC8558827/ /pubmed/34737637 http://dx.doi.org/10.2147/CMAR.S276104 Text en © 2021 Ioffe et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Ioffe, Dina Phull, Pooja Dotan, Efrat Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title | Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title_full | Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title_fullStr | Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title_full_unstemmed | Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title_short | Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review |
title_sort | optimal management of patients with advanced or metastatic cholangiocarcinoma: an evidence-based review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558827/ https://www.ncbi.nlm.nih.gov/pubmed/34737637 http://dx.doi.org/10.2147/CMAR.S276104 |
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