Cargando…

Antitumor Activity of α-Linolenic Acid-Paclitaxel Conjugate Nanoparticles: In vitro and in vivo

PURPOSE: Small molecule modified antitumor drug conjugate nanoparticles have the advantages of high drug loading, simple synthesis and preparation, and better biocompatibility. Due to the large demand for exogenous α-linolenic acid (ALA) by tumor cells, we synthesized α-linolenic acid-paclitaxel con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Mei-Qi, Hao, Yan-Li, Wang, Jing-Ru, Li, Zhuo-Yue, Li, Hui, Feng, Zhen-Han, Wang, Hui, Wang, Jing-Wen, Zhang, Xuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558831/ https://www.ncbi.nlm.nih.gov/pubmed/34737564 http://dx.doi.org/10.2147/IJN.S331578

Ejemplares similares

Antitumor activity of the bioreductive prodrug 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) on MDA-MB-231 cells: in vitro and in vivo
por: Duan, Xiao-Chuan, et al.
Publicado: (2018)

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death
por: Duan, Xiao-Chuan, et al.
Publicado: (2021)

Delivery of baicalein and paclitaxel using self-assembled nanoparticles: synergistic antitumor effect in vitro and in vivo
por: Wang, Wei, et al.
Publicado: (2015)

Effect of XlogP and hansen solubility parameters on the prediction of small molecule modified docetaxel, doxorubicin and irinotecan conjugates forming stable nanoparticles
por: Xu, Mei-Qi, et al.
Publicado: (2021)

Effects of nanoparticle size on antitumor activity of 10-hydroxycamptothecin-conjugated gold nanoparticles: in vitro and in vivo studies
por: Bao, Hanmei, et al.
Publicado: (2016)

α-Linolenic Acid Inhibits RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammation In Vivo
por: Deng, Yufeng, et al.
Publicado: (2023)

Cell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancer
por: Duan, Ziqing, et al.
Publicado: (2017)

α-Linolenic acid but not linolenic acid protects against hypertension: critical role of SIRT3 and autophagic flux
por: Li, Guohua, et al.
Publicado: (2020)

In vivo antitumor effect of endostatin-loaded chitosan nanoparticles combined with paclitaxel on Lewis lung carcinoma
por: Xie, Fang, et al.
Publicado: (2017)

Cancer Chemopreventive Ability of Conjugated Linolenic Acids
por: Tanaka, Takuji, et al.
Publicado: (2011)

Superior antitumor effect of self-assembly supramolecular paclitaxel nanoparticles
por: Yu, Na, et al.
Publicado: (2020)

Absorption and metabolism of conjugated α-linolenic acid given as free fatty acids or triacylglycerols in rats
por: Plourde, Mélanie, et al.
Publicado: (2006)

α-Linolenic Acid–Valproic Acid Conjugates: Toward Single-Molecule Polypharmacology for Multiple Sclerosis
por: Rossi, Michele, et al.
Publicado: (2020)

Synergistic Antitumor Effects of Novel HDAC Inhibitors and Paclitaxel In Vitro and In Vivo
por: Zuco, Valentina, et al.
Publicado: (2011)

A novel preparative method for nanoparticle albumin-bound paclitaxel with high drug loading and its evaluation both in vitro and in vivo
por: Gao, Yue, et al.
Publicado: (2021)

Biohydrogenation Pathway of α-Linolenic Acid in Rumen of Dairy Cow In Vitro
por: Huang, Guoxin, et al.
Publicado: (2022)

The impact of liposomal linolenic acid on gastrointestinal microbiota in mice
por: Li, Xuan-xuan, et al.
Publicado: (2018)

In vitro and in vivo antitumor effect of gefitinib nanoparticles on human lung cancer
por: Ni, Xiao Ling, et al.
Publicado: (2017)

Potentiation of in vivo Antitumor Effects of Recombinant Interleukin‐1α by Gelatin Conjugation
por: Tabata, Yasuhiko, et al.
Publicado: (1993)

Evaluation of antitumor activity of survivin short interfering RNA delivered by lipid nanoparticles in colon cancer in vitro and in vivo
por: Wang, Tianyou, et al.
Publicado: (2017)

Modulatory Effects of Biosynthesized Gold Nanoparticles Conjugated with Curcumin and Paclitaxel on Tumorigenesis and Metastatic Pathways—In Vitro and In Vivo Studies
por: Vemuri, Satish Kumar, et al.
Publicado: (2022)

Optimization, Characterization and in vivo Evaluation of Paclitaxel-Loaded Folate-Conjugated Superparamagnetic Iron Oxide Nanoparticles
por: Gui, Gang, et al.
Publicado: (2021)

Dietary Intake and Biomarkers of α-Linolenic Acid and Mortality: A Meta-Analysis of Prospective Cohort Studies
por: Chen, Li-Hua, et al.
Publicado: (2021)

Hyaluronan Oligosaccharides-Coated Paclitaxel-Casein Nanoparticles with Enhanced Stability and Antitumor Activity
por: Wang, Man, et al.
Publicado: (2022)

The synergic antitumor effects of paclitaxel and temozolomide co-loaded in mPEG-PLGA nanoparticles on glioblastoma cells
por: Xu, Yuanyuan, et al.
Publicado: (2016)

Paclitaxel-loaded PLGA microspheres with a novel morphology to facilitate drug delivery and antitumor efficiency
por: Zhang, Zongrui, et al.
Publicado: (2018)

In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration
por: Zeng, Huahui, et al.
Publicado: (2020)

Probing the fluorination effect on the self-assembly characteristics, in vivo fate and antitumor efficacy of paclitaxel prodrug nanoassemblies
por: Wang, Xin, et al.
Publicado: (2021)

Erythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy
por: Zhai, Zheng, et al.
Publicado: (2020)

Enhanced Solubility and Antitumor Activity of Annona Squamosa Seed Oil via Nanoparticles Stabilized with TPGS: Preparation and In Vitro and In Vivo Evaluation
por: Ao, Hui, et al.
Publicado: (2022)

Crocin Exhibits Antitumor Effects on Human Leukemia HL-60 Cells In Vitro and In Vivo
por: Sun, Yan, et al.
Publicado: (2013)

Targeted paclitaxel‐octreotide conjugates inhibited the growth of paclitaxel‐resistant human non‐small cell lung cancer A549 cells in vitro
por: Liu, Yanguo, et al.
Publicado: (2021)

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1
por: Beatty, Alexander, et al.
Publicado: (2021)

Evodiamine inactivates NF-κB and potentiates the antitumor effects of gemcitabine on tongue cancer both in vitro and in vivo
por: Guo, Qi, et al.
Publicado: (2018)

Physicochemical properties and biocompatibility of a polymer-paclitaxel conjugate for cancer treatment
por: Yang, Danbo, et al.
Publicado: (2011)

Production of Conjugated Linoleic and Conjugated α-Linolenic Acid in a Reconstituted Skim Milk-Based Medium by Bifidobacterial Strains Isolated from Human Breast Milk
por: Villar-Tajadura, María Antonia, et al.
Publicado: (2014)

The theranostic efficiency of tumor-specific, pH-responsive, peptide-modified, liposome-containing paclitaxel and superparamagnetic iron oxide nanoparticles
por: Zheng, Xiu-Chai, et al.
Publicado: (2018)

Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid–paclitaxel (CLA-PTX) on B16-F10 melanoma
por: Du, Ruo, et al.
Publicado: (2014)

Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo
por: Han, Xiqian, et al.
Publicado: (2015)

A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, and In Vivo Antitumor Efficacy and Safety
por: Wang, Ying, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7cr8pqleq3aiqgph3rgln8v6ui