Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome

Tactical disruption of protein synthesis is an attractive therapeutic strategy, with the first-in-class eIF4A-targeting compound zotatifin in clinical evaluation for cancer and COVID-19. The full cellular impact and mechanisms of these potent molecules are undefined at a proteomic level. Here, we re...

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Detalles Bibliográficos
Autores principales: Ho, J.J. David, Cunningham, Tyler A., Manara, Paola, Coughlin, Caroline A., Arumov, Artavazd, Roberts, Evan R., Osteen, Ashanti, Kumar, Preet, Bilbao, Daniel, Krieger, Jonathan R., Lee, Stephen, Schatz, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558842/
https://www.ncbi.nlm.nih.gov/pubmed/34644561
http://dx.doi.org/10.1016/j.celrep.2021.109806

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