Coexpression network analysis identified lncRNAs-mRNAs with potential relevance in African ancestry prostate cancer

AIM: This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients. METHODS: We performed weighted gene coexpression network analysis of the expression from 49 o...

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Detalles Bibliográficos
Autores principales: Parra-Medina, Rafael, López-Kleine, Liliana, Ramírez-Clavijo, Sandra, Payán-Gómez, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558852/
https://www.ncbi.nlm.nih.gov/pubmed/34737889
http://dx.doi.org/10.2144/fsoa-2021-0076
Descripción
Sumario:AIM: This study aims to investigate similarities and differences using lncRNA and mRNA coexpression network analysis in African ancestry (AA) and European ancestry (EA) among prostate cancer (PCa) patients. METHODS: We performed weighted gene coexpression network analysis of the expression from 49 of AA and 49 of EA to identify lncRNAs-mRNAs. RESULTS: 27 lncRNAs and 36 mRNAs were highly expressed in patients of AA. Two mRNAs and their antisense lncRNAs were expressed. Additionally, seven mRNAs were DE or coexpressed and had an impact on survival. CONCLUSION: We present a list of lncRNAs and mRNAs that were DE and coexpressed when comparing patients of AA and EA, and these data are a resource for future studies to understand the role of lncRNAs.

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