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Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke

Background  Stroke is the second leading cause of death in the world and a major cause of disability, with ischemic stroke contributing to 87% of all strokes. Platelets are central in the formation of thrombus, and in the process, they enlarge in size, become active, and secrete prothrombotic factor...

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Autores principales: OT, Sreejith, Zafar, Lubna, Beg, Mujahid, Siddiqui, Obaid Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558973/
https://www.ncbi.nlm.nih.gov/pubmed/34737513
http://dx.doi.org/10.1055/s-0041-1735326
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author OT, Sreejith
Zafar, Lubna
Beg, Mujahid
Siddiqui, Obaid Ahmed
author_facet OT, Sreejith
Zafar, Lubna
Beg, Mujahid
Siddiqui, Obaid Ahmed
author_sort OT, Sreejith
collection PubMed
description Background  Stroke is the second leading cause of death in the world and a major cause of disability, with ischemic stroke contributing to 87% of all strokes. Platelets are central in the formation of thrombus, and in the process, they enlarge in size, become active, and secrete prothrombotic factors. This is supported by the presence of large platelets in ischemic stroke, where they may be implicated in the pathogenesis of vessel occlusion, leading to stroke. The mean platelet volume (MPV) is an important laboratory marker of platelet function and activation. Materials and Methods  The present study was conducted to assess the role of MPV in the pathogenesis, severity, and outcome of ischemic stroke. It was an observational study in 100 acute ischemic stroke (AIS) patients (excluding cardioembolic stroke) admitted to the Medicine wards, Department of Medicine, Jawaharlal Nehru Medical College, a tertiary care hospital at Aligarh. The MPV was correlated with the conventional risk factors of ischemic stroke and outcome (using modified Rankin scale [mRS]). The study revealed statistically significant correlation between MPV and hypertension, type 2 diabetes mellitus, and carotid intima media thickness (CIMT). Also, the MPV at presentation positively correlated with mRS (correlation coefficient 0.818); thus, high MPV was associated with more severe disability. Conclusion  The MPV at the time of presentation of ischemic stroke may be useful in predicting the severity of stroke and neurological recovery. However, a larger study including diverse population is required to endorse its predictive value in AIS.
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spelling pubmed-85589732021-11-03 Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke OT, Sreejith Zafar, Lubna Beg, Mujahid Siddiqui, Obaid Ahmed J Neurosci Rural Pract Background  Stroke is the second leading cause of death in the world and a major cause of disability, with ischemic stroke contributing to 87% of all strokes. Platelets are central in the formation of thrombus, and in the process, they enlarge in size, become active, and secrete prothrombotic factors. This is supported by the presence of large platelets in ischemic stroke, where they may be implicated in the pathogenesis of vessel occlusion, leading to stroke. The mean platelet volume (MPV) is an important laboratory marker of platelet function and activation. Materials and Methods  The present study was conducted to assess the role of MPV in the pathogenesis, severity, and outcome of ischemic stroke. It was an observational study in 100 acute ischemic stroke (AIS) patients (excluding cardioembolic stroke) admitted to the Medicine wards, Department of Medicine, Jawaharlal Nehru Medical College, a tertiary care hospital at Aligarh. The MPV was correlated with the conventional risk factors of ischemic stroke and outcome (using modified Rankin scale [mRS]). The study revealed statistically significant correlation between MPV and hypertension, type 2 diabetes mellitus, and carotid intima media thickness (CIMT). Also, the MPV at presentation positively correlated with mRS (correlation coefficient 0.818); thus, high MPV was associated with more severe disability. Conclusion  The MPV at the time of presentation of ischemic stroke may be useful in predicting the severity of stroke and neurological recovery. However, a larger study including diverse population is required to endorse its predictive value in AIS. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-09-28 /pmc/articles/PMC8558973/ /pubmed/34737513 http://dx.doi.org/10.1055/s-0041-1735326 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle OT, Sreejith
Zafar, Lubna
Beg, Mujahid
Siddiqui, Obaid Ahmed
Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title_full Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title_fullStr Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title_full_unstemmed Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title_short Association of Mean Platelet Volume with Risk Factors and Functional Outcome in Acute Ischemic Stroke
title_sort association of mean platelet volume with risk factors and functional outcome in acute ischemic stroke
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8558973/
https://www.ncbi.nlm.nih.gov/pubmed/34737513
http://dx.doi.org/10.1055/s-0041-1735326
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