Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature

Hyperammonemic encephalopathy is an uncommon, potentially lethal adverse effect of 5-fluorouracil (5-FU). Being one of the most common and versatile chemotherapy agents, it is important to understand this important side effect of 5FU. There is paucity of data in this subject. Here, we report a case...

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Autores principales: Das, Saikat, Ahmad, Aftab, Prasun, Pallav, Kharade, Vipin, Gupta, Manish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559066/
https://www.ncbi.nlm.nih.gov/pubmed/34737523
http://dx.doi.org/10.1055/s-0041-1736154
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author Das, Saikat
Ahmad, Aftab
Prasun, Pallav
Kharade, Vipin
Gupta, Manish
author_facet Das, Saikat
Ahmad, Aftab
Prasun, Pallav
Kharade, Vipin
Gupta, Manish
author_sort Das, Saikat
collection PubMed
description Hyperammonemic encephalopathy is an uncommon, potentially lethal adverse effect of 5-fluorouracil (5-FU). Being one of the most common and versatile chemotherapy agents, it is important to understand this important side effect of 5FU. There is paucity of data in this subject. Here, we report a case of 5FU-induced encephalopathy in a patient on induction chemotherapy for head and neck cancer. In this case report, the clinical presentation, diagnosis, and management of 5FU-induced encephalopathy is reported.
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spelling pubmed-85590662021-11-03 Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature Das, Saikat Ahmad, Aftab Prasun, Pallav Kharade, Vipin Gupta, Manish J Neurosci Rural Pract Hyperammonemic encephalopathy is an uncommon, potentially lethal adverse effect of 5-fluorouracil (5-FU). Being one of the most common and versatile chemotherapy agents, it is important to understand this important side effect of 5FU. There is paucity of data in this subject. Here, we report a case of 5FU-induced encephalopathy in a patient on induction chemotherapy for head and neck cancer. In this case report, the clinical presentation, diagnosis, and management of 5FU-induced encephalopathy is reported. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-09-28 /pmc/articles/PMC8559066/ /pubmed/34737523 http://dx.doi.org/10.1055/s-0041-1736154 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Das, Saikat
Ahmad, Aftab
Prasun, Pallav
Kharade, Vipin
Gupta, Manish
Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title_full Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title_fullStr Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title_full_unstemmed Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title_short Hyperammonemic Encephalopathy Associated with 5-Flurouracil Infusion in Head and Neck Cancer: Case Report and Review of the Literature
title_sort hyperammonemic encephalopathy associated with 5-flurouracil infusion in head and neck cancer: case report and review of the literature
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559066/
https://www.ncbi.nlm.nih.gov/pubmed/34737523
http://dx.doi.org/10.1055/s-0041-1736154
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