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COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study

OBJECTIVES: We aimed to explore the seroprevalence of hospital staff comparing to preprocedural patients in Thai community hospitals to shed light on the situation of COVID-19 infection of frontline healthcare workers in low infection rate countries where mass screening was not readily available. DE...

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Autores principales: Nopsopon, Tanawin, Pongpirul, Krit, Chotirosniramit, Korn, Hiransuthikul, Narin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559109/
https://www.ncbi.nlm.nih.gov/pubmed/34716155
http://dx.doi.org/10.1136/bmjopen-2020-046676
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author Nopsopon, Tanawin
Pongpirul, Krit
Chotirosniramit, Korn
Hiransuthikul, Narin
author_facet Nopsopon, Tanawin
Pongpirul, Krit
Chotirosniramit, Korn
Hiransuthikul, Narin
author_sort Nopsopon, Tanawin
collection PubMed
description OBJECTIVES: We aimed to explore the seroprevalence of hospital staff comparing to preprocedural patients in Thai community hospitals to shed light on the situation of COVID-19 infection of frontline healthcare workers in low infection rate countries where mass screening was not readily available. DESIGN: Cross-sectional study. SETTING: 52 community hospitals in 35 provinces covered all regions of Thailand. PARTICIPANTS: 857 participants consisted of 675 hospital staff and 182 preprocedural patients. OUTCOME MEASURE: COVID-19 seroprevalence using a locally developed rapid IgM/IgG test kit RESULTS: Overall, 5.5% of the participants (47 of 857) had positive IgM, 0.2% (2 of 857) had positive IgG which both of them also had positive IgM. Hospitals located in the central part of Thailand had the highest IgM seroprevalence (11.9%). Preprocedural patients had a higher rate of positive IgM than the hospital staff (12.1% vs 3.7%). Participants with present upper respiratory tract symptoms had a higher rate of positive IgM than those without (9.6% vs 4.5%). Three quarters (80.5%, 690 of 857) of the participants were asymptomatic, of which, 31 had positive IgM (4.5%) which consisted of 20 of 566 healthcare workers (3.5%) and 11 of 124 preprocedural patients (8.9%). CONCLUSIONS: COVID-19 antibody test could detect a substantial number of potential silent spreaders in Thai community hospitals where the nasopharyngeal PCR was not readily available, and the antigen test was prohibited. Antibody testing should be encouraged for mass screening in a limited resource setting, especially in asymptomatic individuals. TRIAL REGISTRATION: TCTR20200426002.
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spelling pubmed-85591092021-11-02 COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study Nopsopon, Tanawin Pongpirul, Krit Chotirosniramit, Korn Hiransuthikul, Narin BMJ Open Epidemiology OBJECTIVES: We aimed to explore the seroprevalence of hospital staff comparing to preprocedural patients in Thai community hospitals to shed light on the situation of COVID-19 infection of frontline healthcare workers in low infection rate countries where mass screening was not readily available. DESIGN: Cross-sectional study. SETTING: 52 community hospitals in 35 provinces covered all regions of Thailand. PARTICIPANTS: 857 participants consisted of 675 hospital staff and 182 preprocedural patients. OUTCOME MEASURE: COVID-19 seroprevalence using a locally developed rapid IgM/IgG test kit RESULTS: Overall, 5.5% of the participants (47 of 857) had positive IgM, 0.2% (2 of 857) had positive IgG which both of them also had positive IgM. Hospitals located in the central part of Thailand had the highest IgM seroprevalence (11.9%). Preprocedural patients had a higher rate of positive IgM than the hospital staff (12.1% vs 3.7%). Participants with present upper respiratory tract symptoms had a higher rate of positive IgM than those without (9.6% vs 4.5%). Three quarters (80.5%, 690 of 857) of the participants were asymptomatic, of which, 31 had positive IgM (4.5%) which consisted of 20 of 566 healthcare workers (3.5%) and 11 of 124 preprocedural patients (8.9%). CONCLUSIONS: COVID-19 antibody test could detect a substantial number of potential silent spreaders in Thai community hospitals where the nasopharyngeal PCR was not readily available, and the antigen test was prohibited. Antibody testing should be encouraged for mass screening in a limited resource setting, especially in asymptomatic individuals. TRIAL REGISTRATION: TCTR20200426002. BMJ Publishing Group 2021-10-28 /pmc/articles/PMC8559109/ /pubmed/34716155 http://dx.doi.org/10.1136/bmjopen-2020-046676 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Epidemiology
Nopsopon, Tanawin
Pongpirul, Krit
Chotirosniramit, Korn
Hiransuthikul, Narin
COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title_full COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title_fullStr COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title_full_unstemmed COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title_short COVID-19 seroprevalence among hospital staff and preprocedural patients in Thai community hospitals: a cross-sectional study
title_sort covid-19 seroprevalence among hospital staff and preprocedural patients in thai community hospitals: a cross-sectional study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559109/
https://www.ncbi.nlm.nih.gov/pubmed/34716155
http://dx.doi.org/10.1136/bmjopen-2020-046676
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