Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy

BACKGROUND: A profound insight into the immune landscape of vulvar squamous cell carcinoma (VSCC) is lacking. Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expression was performed in early-stage and late-stage VSCC. METHO...

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Detalles Bibliográficos
Autores principales: Kortekaas, Kim E, Santegoets, Saskia J, Tas, Liselotte, Ehsan, Ilina, Charoentong, Pornpimol, van Doorn, Helena C, van Poelgeest, Mariette I E, Mustafa, Dana A M, van der Burg, Sjoerd H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559240/
https://www.ncbi.nlm.nih.gov/pubmed/34716208
http://dx.doi.org/10.1136/jitc-2021-003671

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