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Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity

BACKGROUND: Near-infrared photoimmunotherapy (NIR-PIT) is a new modality for treating cancer, which uses antibody-photoabsorber (IRDye700DX) conjugates that specifically bind to target tumor cells. This conjugate is then photoactivated by NIR light, inducing rapid necrotic cell death. NIR-PIT needs...

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Detalles Bibliográficos
Autores principales:	Taki, Shunichi, Matsuoka, Kohei, Nishinaga, Yuko, Takahashi, Kazuomi, Yasui, Hirotoshi, Koike, Chiaki, Shimizu, Misae, Sato, Mitsuo, Sato, Kazuhide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559243/ https://www.ncbi.nlm.nih.gov/pubmed/34725216 http://dx.doi.org/10.1136/jitc-2021-003036

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