Role of Oxidative Stress and Autophagy in Thoracic Aortic Aneurysms

Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displaye...

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Detalles Bibliográficos
Autores principales: Irace, Francesco G., Cammisotto, Vittoria, Valenti, Valentina, Forte, Maurizio, Schirone, Leonardo, Bartimoccia, Simona, Iaccarino, Alessandra, Peruzzi, Mariangela, Schiavon, Sonia, Morelli, Andrea, Marullo, Antonino G.M., Miraldi, Fabio, Nocella, Cristina, De Paulis, Ruggero, Benedetto, Umberto, Greco, Ernesto, Biondi-Zoccai, Giuseppe, Sciarretta, Sebastiano, Carnevale, Roberto, Frati, Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559314/
https://www.ncbi.nlm.nih.gov/pubmed/34754985
http://dx.doi.org/10.1016/j.jacbts.2021.08.002
Descripción
Sumario:Thoracic aortic aneurysms (TAA) pathogenesis and progression include many mechanisms. The authors investigated the role of autophagy, oxidative stress, and endothelial dysfunction in 36 TAA patients and 23 control patients. Univariable and multivariable analyses were performed. TAA patients displayed higher oxidative stress and endothelial dysfunction then control patients. Autophagy in the TAA group was reduced. The association of oxidative stress and autophagy with aortic disease supports the role of these processes in TAA. The authors demonstrate a putative role of Nox2 and autophagy dysregulation in human TAA. These findings could pinpoint novel treatment targets to prevent or limit TAA progression.

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