Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse (14)C Dating

Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the (14)C bomb-pulse dating method, we assessed the physical age of atherosclerotic...

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Detalles Bibliográficos
Autores principales: Edsfeldt, Andreas, Stenström, Kristina Eriksson, Sun, Jiangming, Dias, Nuno, Skog, Göran, Singh, Pratibha, Mattsson, Sören, Nilsson, Jan, Gonçalves, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559321/
https://www.ncbi.nlm.nih.gov/pubmed/34754987
http://dx.doi.org/10.1016/j.jacbts.2021.08.005
Descripción
Sumario:Individuals with rapidly progressing atherosclerotic plaques are at higher risk of experiencing acute complications. Currently, we lack knowledge regarding factors in human plaque that cause rapid progression. Using the (14)C bomb-pulse dating method, we assessed the physical age of atherosclerotic plaques and which biological processes were associated with rapidly progressing plaques. Interestingly, increased apoptosis was the main component associated with a young physical plaque age, reflecting rapid plaque progression. Our findings in combination with recent advances in imaging techniques could guide future diagnostic imaging strategies to identify rapidly progressing plaques or therapeutic targets, halting plaque progression.

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