Lysosomal Zn(2+) release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma

During tumor progression, lysosome function is often maladaptively upregulated to match the high energy demand required for cancer cell hyper-proliferation and invasion. Here, we report that mucolipin TRP channel 1 (TRPML1), a lysosomal Ca(2+) and Zn(2+) release channel that regulates multiple aspec...

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Detalles Bibliográficos
Autores principales: Du, Wanlu, Gu, Mingxue, Hu, Meiqin, Pinchi, Prateeksunder, Chen, Wei, Ryan, Michael, Nold, Timothy, Bannaga, Ahmed, Xu, Haoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559338/
https://www.ncbi.nlm.nih.gov/pubmed/34686351
http://dx.doi.org/10.1016/j.celrep.2021.109848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559338/
https://www.ncbi.nlm.nih.gov/pubmed/34686351
http://dx.doi.org/10.1016/j.celrep.2021.109848

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