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Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism
Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflam...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559508/ https://www.ncbi.nlm.nih.gov/pubmed/34733165 http://dx.doi.org/10.3389/fphar.2021.767243 |
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author | Peng, Xiaoyuan Ma, Yiyang Wang, Qiyang Gao, Yanchun Li, Guangyi Jiang, Chenyi Gao, Yun Feng, Yong |
author_facet | Peng, Xiaoyuan Ma, Yiyang Wang, Qiyang Gao, Yanchun Li, Guangyi Jiang, Chenyi Gao, Yun Feng, Yong |
author_sort | Peng, Xiaoyuan |
collection | PubMed |
description | Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflammation and we found that SAA is increased for the first time in the serum of ONFH patients through proteomic studies and quantitatively verified by ELISA. Treating rBMSCs with SAA inhibited the osteogenic differentiation via Wnt/β-catenin signaling pathway deactivation and enhanced the adipogenic differentiation via MAPK/PPARγ signaling pathway activation. Finally, bilateral critical-sized calvarial-defect rat model which received SAA treated rBMSCs demonstrated reduction of bone formation when compared to untreated rBMSCs implantation control. Hence, SAA is a vital protein in the physiological process of ONFH and can act as a potential therapeutic target to treat ONFH. |
format | Online Article Text |
id | pubmed-8559508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-85595082021-11-02 Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism Peng, Xiaoyuan Ma, Yiyang Wang, Qiyang Gao, Yanchun Li, Guangyi Jiang, Chenyi Gao, Yun Feng, Yong Front Pharmacol Pharmacology Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflammation and we found that SAA is increased for the first time in the serum of ONFH patients through proteomic studies and quantitatively verified by ELISA. Treating rBMSCs with SAA inhibited the osteogenic differentiation via Wnt/β-catenin signaling pathway deactivation and enhanced the adipogenic differentiation via MAPK/PPARγ signaling pathway activation. Finally, bilateral critical-sized calvarial-defect rat model which received SAA treated rBMSCs demonstrated reduction of bone formation when compared to untreated rBMSCs implantation control. Hence, SAA is a vital protein in the physiological process of ONFH and can act as a potential therapeutic target to treat ONFH. Frontiers Media S.A. 2021-10-18 /pmc/articles/PMC8559508/ /pubmed/34733165 http://dx.doi.org/10.3389/fphar.2021.767243 Text en Copyright © 2021 Peng, Ma, Wang, Gao, Li, Jiang, Gao and Feng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Peng, Xiaoyuan Ma, Yiyang Wang, Qiyang Gao, Yanchun Li, Guangyi Jiang, Chenyi Gao, Yun Feng, Yong Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title | Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title_full | Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title_fullStr | Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title_full_unstemmed | Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title_short | Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism |
title_sort | serum amyloid a correlates with the osteonecrosis of femoral head by affecting bone metabolism |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559508/ https://www.ncbi.nlm.nih.gov/pubmed/34733165 http://dx.doi.org/10.3389/fphar.2021.767243 |
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