Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

Background: While physiologically based pharmacokinetic (PBPK) models generally predict pharmacokinetics in pregnant women successfully, the confidence in predicting fetal pharmacokinetics is limited because many parameters affecting placental drug transfer have not been mechanistically accounted fo...

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Detalles Bibliográficos
Autores principales: Liu, Xiaomei I., Green, Dionna J., van den Anker, John N., Rakhmanina, Natella Y., Ahmadzia, Homa K., Momper, Jeremiah D., Park, Kyunghun, Burckart, Gilbert J., Dallmann, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559552/
https://www.ncbi.nlm.nih.gov/pubmed/34733804
http://dx.doi.org/10.3389/fped.2021.723006

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