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Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response

Nucleic acid–sensing pathways play critical roles in innate immune activation through the production of type I interferon (IFN-I) and proinflammatory cytokines. These factors are required for effective antitumor immune responses. Pharmacological modulators of the pre-mRNA spliceosome splicing factor...

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Detalles Bibliográficos
Autores principales:	Chang, Aaron Y., Zhou, Yu Jerry, Iyengar, Sharanya, Pobiarzyn, Piotr W., Tishchenko, Pavel, Shah, Kesha M., Wheeler, Heather, Wang, Yue-Ming, Loria, Paula M., Loganzo, Frank, Woo, Seng-Ryong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559577/ https://www.ncbi.nlm.nih.gov/pubmed/34619148 http://dx.doi.org/10.1016/j.jbc.2021.101277

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