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Tumor invasion to the spinal region after primary surgery: A case report
BACKGROUND: It is believed that pituitary carcinoma is a rare disorder and arise from the transformation of benign invasive macroadenomas, and the process of this transformation takes place slowly. CASE PRESENTATION: A 51-year-old man presented with the clinical features of Cushing syndrome and walk...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Babol University of Medical Sciences
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559627/ https://www.ncbi.nlm.nih.gov/pubmed/34760107 http://dx.doi.org/10.22088/cjim.12.0.467 |
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author | Davoudi, Zahra Chouhdari, Arezoo Sharifi, Guive Akbari Dilmaghani, Nader |
author_facet | Davoudi, Zahra Chouhdari, Arezoo Sharifi, Guive Akbari Dilmaghani, Nader |
author_sort | Davoudi, Zahra |
collection | PubMed |
description | BACKGROUND: It is believed that pituitary carcinoma is a rare disorder and arise from the transformation of benign invasive macroadenomas, and the process of this transformation takes place slowly. CASE PRESENTATION: A 51-year-old man presented with the clinical features of Cushing syndrome and walking impairment who was diagnosed with metastatic corticotroph pituitary carcinoma to the spine region, 6 years after the initial resection of a primary invasive pituitary adenoma. He made a visit to neurosurgery and endocrinology clinic with the chief complaint of weight gain, facial and extremities swelling, paresthesia, weakness, motion and speaking impairments, and HTN which all appeared through the last 1 year; hormonal laboratory tests showed urine free cortisol (UFC) 197.8 and 367. 30 ug/24hrs (36-137), cortisol 8 am after 1 mg overnight dexamethasone test 375 ng/mL (50-250) and ACTH 59 pg/mL. MRI study revealed a mass in the brainstem with the compression effect on spinal region, pituitary imagine does not differ from the last MRI. He underwent a neurosurgery for spinal mass resection, which was successful and the total mass was resected. After surgery, the patient's condition became better. CONCLUSION: Pituitary carcinoma is a rare entity impossible to recognize as a primary tumor because its diagnosis by definition requires the presence of metastasis. Clinical awareness of the rare possibility for aggressive adenomas will progress, to metastasize is essential to appropriately monitor patients for possible early detection and treatment of pituitary carcinoma. |
format | Online Article Text |
id | pubmed-8559627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Babol University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-85596272021-11-09 Tumor invasion to the spinal region after primary surgery: A case report Davoudi, Zahra Chouhdari, Arezoo Sharifi, Guive Akbari Dilmaghani, Nader Caspian J Intern Med Case Report BACKGROUND: It is believed that pituitary carcinoma is a rare disorder and arise from the transformation of benign invasive macroadenomas, and the process of this transformation takes place slowly. CASE PRESENTATION: A 51-year-old man presented with the clinical features of Cushing syndrome and walking impairment who was diagnosed with metastatic corticotroph pituitary carcinoma to the spine region, 6 years after the initial resection of a primary invasive pituitary adenoma. He made a visit to neurosurgery and endocrinology clinic with the chief complaint of weight gain, facial and extremities swelling, paresthesia, weakness, motion and speaking impairments, and HTN which all appeared through the last 1 year; hormonal laboratory tests showed urine free cortisol (UFC) 197.8 and 367. 30 ug/24hrs (36-137), cortisol 8 am after 1 mg overnight dexamethasone test 375 ng/mL (50-250) and ACTH 59 pg/mL. MRI study revealed a mass in the brainstem with the compression effect on spinal region, pituitary imagine does not differ from the last MRI. He underwent a neurosurgery for spinal mass resection, which was successful and the total mass was resected. After surgery, the patient's condition became better. CONCLUSION: Pituitary carcinoma is a rare entity impossible to recognize as a primary tumor because its diagnosis by definition requires the presence of metastasis. Clinical awareness of the rare possibility for aggressive adenomas will progress, to metastasize is essential to appropriately monitor patients for possible early detection and treatment of pituitary carcinoma. Babol University of Medical Sciences 2021 /pmc/articles/PMC8559627/ /pubmed/34760107 http://dx.doi.org/10.22088/cjim.12.0.467 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Davoudi, Zahra Chouhdari, Arezoo Sharifi, Guive Akbari Dilmaghani, Nader Tumor invasion to the spinal region after primary surgery: A case report |
title | Tumor invasion to the spinal region after primary surgery: A case report |
title_full | Tumor invasion to the spinal region after primary surgery: A case report |
title_fullStr | Tumor invasion to the spinal region after primary surgery: A case report |
title_full_unstemmed | Tumor invasion to the spinal region after primary surgery: A case report |
title_short | Tumor invasion to the spinal region after primary surgery: A case report |
title_sort | tumor invasion to the spinal region after primary surgery: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559627/ https://www.ncbi.nlm.nih.gov/pubmed/34760107 http://dx.doi.org/10.22088/cjim.12.0.467 |
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