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Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559673/ https://www.ncbi.nlm.nih.gov/pubmed/34725126 http://dx.doi.org/10.1101/gad.349053.121 |
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author | Rabhi, Nabil Farmer, Stephen R. |
author_facet | Rabhi, Nabil Farmer, Stephen R. |
author_sort | Rabhi, Nabil |
collection | PubMed |
description | Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed thermogenic beige adipocytes within white depots in response to catecholamines secretion. Coordinated cellular interaction between different cell types within the tissue and a fine-tuned transcriptional program synergistically take place to promote beige remodeling. However, both cell–cell interactions and molecular mechanisms governing beige adipocyte appearance and maintenance are poorly understood. In this and the previous issue of Genes & Development, Shao and colleagues (pp. 1461–1474) and Shan and colleagues (pp. 1333–1338) advance our understanding of these issues and, in doing so, highlight potential therapeutic strategies to combat obesity-associated diseases. |
format | Online Article Text |
id | pubmed-8559673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-85596732022-05-01 Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies Rabhi, Nabil Farmer, Stephen R. Genes Dev Outlook Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed thermogenic beige adipocytes within white depots in response to catecholamines secretion. Coordinated cellular interaction between different cell types within the tissue and a fine-tuned transcriptional program synergistically take place to promote beige remodeling. However, both cell–cell interactions and molecular mechanisms governing beige adipocyte appearance and maintenance are poorly understood. In this and the previous issue of Genes & Development, Shao and colleagues (pp. 1461–1474) and Shan and colleagues (pp. 1333–1338) advance our understanding of these issues and, in doing so, highlight potential therapeutic strategies to combat obesity-associated diseases. Cold Spring Harbor Laboratory Press 2021-11-01 /pmc/articles/PMC8559673/ /pubmed/34725126 http://dx.doi.org/10.1101/gad.349053.121 Text en © 2021 Rabhi and Farmer; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Outlook Rabhi, Nabil Farmer, Stephen R. Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title | Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title_full | Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title_fullStr | Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title_full_unstemmed | Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title_short | Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
title_sort | unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559673/ https://www.ncbi.nlm.nih.gov/pubmed/34725126 http://dx.doi.org/10.1101/gad.349053.121 |
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