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Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies

Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed t...

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Detalles Bibliográficos
Autores principales: Rabhi, Nabil, Farmer, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559673/
https://www.ncbi.nlm.nih.gov/pubmed/34725126
http://dx.doi.org/10.1101/gad.349053.121
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author Rabhi, Nabil
Farmer, Stephen R.
author_facet Rabhi, Nabil
Farmer, Stephen R.
author_sort Rabhi, Nabil
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description Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed thermogenic beige adipocytes within white depots in response to catecholamines secretion. Coordinated cellular interaction between different cell types within the tissue and a fine-tuned transcriptional program synergistically take place to promote beige remodeling. However, both cell–cell interactions and molecular mechanisms governing beige adipocyte appearance and maintenance are poorly understood. In this and the previous issue of Genes & Development, Shao and colleagues (pp. 1461–1474) and Shan and colleagues (pp. 1333–1338) advance our understanding of these issues and, in doing so, highlight potential therapeutic strategies to combat obesity-associated diseases.
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spelling pubmed-85596732022-05-01 Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies Rabhi, Nabil Farmer, Stephen R. Genes Dev Outlook Adipose tissue is a complex organ consisting of a mixture of mature adipocytes and stromal vascular cells. It displays a remarkable ability to adapt to environmental and dietary cues by changing its morphology and metabolic capacity. This plasticity is demonstrated by the emergence of interspersed thermogenic beige adipocytes within white depots in response to catecholamines secretion. Coordinated cellular interaction between different cell types within the tissue and a fine-tuned transcriptional program synergistically take place to promote beige remodeling. However, both cell–cell interactions and molecular mechanisms governing beige adipocyte appearance and maintenance are poorly understood. In this and the previous issue of Genes & Development, Shao and colleagues (pp. 1461–1474) and Shan and colleagues (pp. 1333–1338) advance our understanding of these issues and, in doing so, highlight potential therapeutic strategies to combat obesity-associated diseases. Cold Spring Harbor Laboratory Press 2021-11-01 /pmc/articles/PMC8559673/ /pubmed/34725126 http://dx.doi.org/10.1101/gad.349053.121 Text en © 2021 Rabhi and Farmer; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Outlook
Rabhi, Nabil
Farmer, Stephen R.
Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title_full Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title_fullStr Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title_full_unstemmed Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title_short Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
title_sort unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559673/
https://www.ncbi.nlm.nih.gov/pubmed/34725126
http://dx.doi.org/10.1101/gad.349053.121
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