Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes

Hematopoietic stem and progenitor cells (HSPCs) are generated de novo in the embryo from hemogenic endothelial cells (HECs) via an endothelial-to-hematopoietic transition (EHT) that requires the transcription factor RUNX1. Ectopic expression of RUNX1 alone can efficiently promote EHT and HSPC format...

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Detalles Bibliográficos
Autores principales: Howell, Elizabeth D., Yzaguirre, Amanda D., Gao, Peng, Lis, Raphael, He, Bing, Lakadamyali, Melike, Rafii, Shahin, Tan, Kai, Speck, Nancy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559682/
https://www.ncbi.nlm.nih.gov/pubmed/34675061
http://dx.doi.org/10.1101/gad.348738.121

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