Nuclease deficiencies alter plasma cell-free DNA methylation profiles

The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. Compared to wild-type cfDNA, cfDNA in DNASE1L3-deficient mice was significantly hypomethylated, while cfDNA in DNASE1-defic...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Diana S.C., Ni, Meng, Chan, Rebecca W.Y., Wong, Danny K.L., Hiraki, Linda T., Volpi, Stefano, Jiang, Peiyong, Lui, Kathy O., Chan, K.C. Allen, Chiu, Rossa W.K., Lo, Y.M. Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559716/
https://www.ncbi.nlm.nih.gov/pubmed/34470801
http://dx.doi.org/10.1101/gr.275426.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559716/
https://www.ncbi.nlm.nih.gov/pubmed/34470801
http://dx.doi.org/10.1101/gr.275426.121

Ejemplares similares