Cargando…

Nuclease deficiencies alter plasma cell-free DNA methylation profiles

The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. Compared to wild-type cfDNA, cfDNA in DNASE1L3-deficient mice was significantly hypomethylated, while cfDNA in DNASE1-defic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Diana S.C., Ni, Meng, Chan, Rebecca W.Y., Wong, Danny K.L., Hiraki, Linda T., Volpi, Stefano, Jiang, Peiyong, Lui, Kathy O., Chan, K.C. Allen, Chiu, Rossa W.K., Lo, Y.M. Dennis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559716/ https://www.ncbi.nlm.nih.gov/pubmed/34470801 http://dx.doi.org/10.1101/gr.275426.121

Ejemplares similares

Effects of nucleases on cell-free extrachromosomal circular DNA
por: Sin, Sarah T.K., et al.
Publicado: (2022)

The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB
por: Han, Diana S.C., et al.
Publicado: (2020)

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction
por: Chan, Rebecca W.Y., et al.
Publicado: (2020)

Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models
por: Chen, Meihui, et al.
Publicado: (2022)

Enrichment of fetal and maternal long cell‐free DNA fragments from maternal plasma following DNA repair
por: Vong, Joaquim S.L., et al.
Publicado: (2019)

Detection and characterization of jagged ends of double-stranded DNA in plasma
por: Jiang, Peiyong, et al.
Publicado: (2020)

Tracing SARS-Coronavirus Variant with Large Genomic Deletion
por: Chiu, Rossa W.K., et al.
Publicado: (2005)

Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study
por: Chan, KC Allen, et al.
Publicado: (2005)

Cell‐free fetal DNA coming in all sizes and shapes
por: Chiu, Rossa W. K., et al.
Publicado: (2021)

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients
por: Lee, Nelson, et al.
Publicado: (2004)

Noninvasive Prenatal Diagnosis of Fetal Trisomy 21 by Allelic Ratio Analysis Using Targeted Massively Parallel Sequencing of Maternal Plasma DNA
por: Liao, Gary J. W., et al.
Publicado: (2012)

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin
por: Sun, Kun, et al.
Publicado: (2019)

Automated extraction protocol for quantification of SARS-Coronavirus RNA in serum: an evaluation study
por: Chiu, Rossa WK, et al.
Publicado: (2006)

A simple and rapid approach for screening of SARS-coronavirus genotypes: an evaluation study
por: Chung, Grace TY, et al.
Publicado: (2005)

High Resolution Size Analysis of Fetal DNA in the Urine of Pregnant Women by Paired-End Massively Parallel Sequencing
por: Tsui, Nancy B. Y., et al.
Publicado: (2012)

Identification and characterization of extrachromosomal circular DNA in maternal plasma
por: Sin, Sarah T. K., et al.
Publicado: (2020)

Methy-Pipe: An Integrated Bioinformatics Pipeline for Whole Genome Bisulfite Sequencing Data Analysis
por: Jiang, Peiyong, et al.
Publicado: (2014)

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing
por: Sun, Kun, et al.
Publicado: (2018)

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology
por: Gai, Wanxia, et al.
Publicado: (2021)

Epigenetic analysis of cell-free DNA by fragmentomic profiling
por: Zhou, Qing, et al.
Publicado: (2022)

Genome-wide detection of cytosine methylation by single molecule real-time sequencing
por: Tse, O. Y. Olivia, et al.
Publicado: (2021)

Fetal mitochondrial DNA in maternal plasma in surrogate pregnancies: Detection and topology
por: Ma, Mary‐Jane L., et al.
Publicado: (2020)

Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma
por: Jiang, Peiyong, et al.
Publicado: (2018)

Dnase1l3 deletion causes aberrations in length and end-motif frequencies in plasma DNA
por: Serpas, Lee, et al.
Publicado: (2019)

FetalQuant(SD): accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA
por: Jiang, Peiyong, et al.
Publicado: (2016)

Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma
por: Yu, Stephanie C. Y., et al.
Publicado: (2021)

Noninvasive Prenatal Molecular Karyotyping from Maternal Plasma
por: Yu, Stephanie C. Y., et al.
Publicado: (2013)

High-resolution analysis for urinary DNA jagged ends
por: Xie, Tingting, et al.
Publicado: (2022)

Sequencing-based counting and size profiling of plasma Epstein–Barr virus DNA enhance population screening of nasopharyngeal carcinoma
por: Lam, W. K. Jacky, et al.
Publicado: (2018)

Genomic Sequencing of the Severe Acute Respiratory Syndrome-Coronavirus
por: Chim, Stephen S. C., et al.
Publicado: (2006)

Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases
por: Lam, W. K. Jacky, et al.
Publicado: (2019)

Maternal Plasma Fetal DNA Fractions in Pregnancies with Low and High Risks for Fetal Chromosomal Aneuploidies
por: Hudecova, Irena, et al.
Publicado: (2014)

SARS-CoV-2 detection by nasal strips: A superior tool for surveillance of paediatric population
por: Chan, Renee W.Y., et al.
Publicado: (2021)

SARS-CoV-2 RNA Detection on Disposable Wooden Chopsticks, Hong Kong
por: Lui, Grace, et al.
Publicado: (2020)

Suppression of influenza virus infection by rhinovirus interference – at the population, individual and cellular levels
por: Tao, Kin P., et al.
Publicado: (2022)

Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs
por: Zhou, Ze, et al.
Publicado: (2023)

Validation of Self-administrated Questionnaire for Psychiatric Disorders in Patients with Functional Dyspepsia
por: Tse, Ada W.Y., et al.
Publicado: (2010)

Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response
por: Ma, Brigette B.Y., et al.
Publicado: (2009)

Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization
por: Zuo, Tao, et al.
Publicado: (2020)

Striving to Protect Patients and Health Care Professionals in Endoscopy Units During Pandemics: From SARS to COVID-19
por: Lui, Rashid N., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sp8qnh1s7mejudng2mmtud3asu