Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

Mutation in the germline is the ultimate source of genetic variation, but little is known about the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we profile the open chromatin landscape of human spermatogonia, the most proliferative cell type of the germline, ide...

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Detalles Bibliográficos
Autores principales: Kaiser, Vera B., Talmane, Lana, Kumar, Yatendra, Semple, Fiona, MacLennan, Marie, FitzPatrick, David R., Taylor, Martin S., Semple, Colin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559717/
https://www.ncbi.nlm.nih.gov/pubmed/34417209
http://dx.doi.org/10.1101/gr.275407.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559717/
https://www.ncbi.nlm.nih.gov/pubmed/34417209
http://dx.doi.org/10.1101/gr.275407.121

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