Design, synthesis and biological evaluation of N-oxide derivatives with potent in vivo antileishmanial activity

Leishmaniasis is a neglected disease that affects 12 million people living mainly in developing countries. Herein, 24 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their antileishmanial activity. Compound 4f, a furoxan derivative, was particularly r...

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Detalles Bibliográficos
Autores principales: Clementino, Leandro da Costa, Fernandes, Guilherme Felipe Santos, Prokopczyk, Igor Muccilo, Laurindo, Wilquer Castro, Toyama, Danyelle, Motta, Bruno Pereira, Baviera, Amanda Martins, Henrique-Silva, Flávio, dos Santos, Jean Leandro, Graminha, Marcia A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559926/
https://www.ncbi.nlm.nih.gov/pubmed/34723989
http://dx.doi.org/10.1371/journal.pone.0259008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8559926/
https://www.ncbi.nlm.nih.gov/pubmed/34723989
http://dx.doi.org/10.1371/journal.pone.0259008

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